Experimental study of etiology and therapeutics of spinal deformity

以日本白兔新品系前脊柱侧凸兔（LSR）为研究对象，对其生长过程中自发发生胸椎前凸或前脊柱侧凸的过程、病理生理及治疗进行了研究。1)组织病理学研究：8-48周龄LSR对异常弯曲脊柱椎体和椎间盘进行组织病理学检查。8周龄时观察到的主要变化是髓核的移位和纤维环的伸展/压缩。12周龄时，发现椎体生长软骨改变。此后，这些变化加剧，24周龄时，观察到骨骺楔入，48周龄时，观察到纤维环空泡化和骨赘形成。2)后路支架切除矫治脊柱畸形的实验研究：8周龄时，第1组LSR在骨膜下切除椎旁肌肉，切除椎旁肌肉，第2组切除椎旁肌肉，第3组切除椎旁肌肉、棘上韧带和棘间韧带。之后，有一种趋势，即第二组的畸形进展小于第一组。第二组与第三组之间无显著性差异。3)激光核切开术矫正脊柱畸形：我们首创了仅供动物使用的新型钕钇铝石榴石（Nd: YAG）激光探针，该探针由23号针和裸露的石英纤维组成，试图矫正LSR脊柱畸形，但未能获得有效的激光照射。因此，我们不得不放弃这项研究。4)激光核切开术治疗椎体生长软骨破坏：年龄16 ~ 20周的LSR已被采用。已经开发的Nd: YAG激光证明是由双腔针和裸露的石英纤维组成的，用于破坏椎体生长软骨。我们正在寻求最佳的照射条件。我们相信，进一步的研究将有助于矫正脊柱侧凸。少

Using a new strain of Japanese white rabbits, the Lordoscoliotic rabbits (LSR), which spontaneously develop thoracic lordosis or lordoscoliosis during the growth, we studied the course, pathophysiology and treatment of spinal deformities.1)Histopathological study : The vertebral body and disc of the abnormally curved spine were histopathologically examined in LSR at 8-48 weeks of age. The major changes observed at 8 weeks of age were translation of the nucleus pulposus and extension/compression of the annulus fibrosus. At 12 week of age, changes of vertebral growth cartilage were found. Thereafter, these changes intensify and at 24 week of age, wedging of the epiphysis was observed and at 48 weeks of age, vacuolation of the annulus fibrosus and formation of osteophytes were seen.2)Experimental study of the resection of posterior elements for the correction of spinal deformity : At 8 weeks of age, first group of LSR were subperiosteally stripped of paravertebral muscles at the level of … More deformity, second group were resected of paravertebral muscles and third group were resected of paravertebral muscles, supraspinatous and interspinatous ligaments. After that, there is a tendency that the progression of the deformity in second group was raiographically lesser than in first group. There was no significant difference between in second and third group.3)Laser nucleotomy for correction of spinal deformity : We pioneered new Neodymium-yttrium-aluminum-garnet (Nd : YAG) laser probe for animal use only which was consisted of 23 gauge needle and a bare quartz fiber, to try to correct the spinal deformity of LSR,but were not able to get effective laser irradiation. So that, we could not but relinquishing this study.4)Laser nucleotomy for destruction of vertebral growth cartilage : LSR whose ages ranged from 16 to 20 weeks have been used. Already developed Nd : YAG laser prove which is consist of double-lumen needle and a bare quartz fiber is utilized to destroy the vertebral growth cartilage. We are now seeking the best irradiating condition. Further investigation will, we believe, be able to pray a part in the correction of scoliosis. Less