Effects of cyclosporin, azathioprine and mizoribin on male reproduction in rats

为探讨环孢菌素(Cs)、硫唑嘌呤(AZP)和咪唑菌素(MZR)对雄性生殖的影响，观察了Cs、AZP和MZR对雄性大鼠生殖功能的影响。Cs、AZP和MZR处理组精子活力在注射Cs后即刻显著降低，并逐渐改善，但AZP和MZR处理组精子活力无明显变化。注射Cs、AZP和MZR 6周后，生精小管出现明显的剂量依赖性损伤。注射AZP和MZR后即刻血清睾酮水平显著降低，但不受Cs的影响。结论Cs、AZP和MZR对大鼠精原细胞有损伤作用，但仅Cs对附睾功能有损伤作用。

The effects of cyclosporin (Cs) , azathioprine (AZP) and mizoribin (MZR) on male reproduction in rats were examined.A dose-dependent decrease in the sperm count in the cauda epididymis was observed 6 weeks after Cs, AZP and MZR were administered. Sperm motility was significantly decreased in each Cs-treated group immediately after the injection of Cs and improved gradually, but was not changed in the AZP or MZR treated groups.Significant dose-dependent damage of the seminiferous tubules was demonstrated 6 weeks after administration of Cs, AZP and MZR.The serum levels of luteinizing hormone and follicle-stimulating hormone remained the same throughout the experiment. The serum level of testosterone was significantly low immediately after the injections of AZP and MZR,but was not changed by that of Cs.In conclusion, Cs, AZP and MZR injured the spermatogonia in rat, but only Cs injured the epididymal function as well.