Experimental and clinical studies on electrocochleographic evaluation of endolymphatic hydrops

电致学指示器可能可用，用于评估内分泌氢（ELH）的内分泌物（ELH）使用实验动物和临床材料进行研究。也就是说，Enlarged Summer Potential （SP）/Action Potential （AP）比率已被公认为与Meniere的疾病经常相关，这种不良性仅在ELH中找到，但也在一些其他内在病理学模型中作为一种严重的损伤。自从几内亚猪ELH模型展示了AP幅度低频率调制程度上的显著下降和AP-延迟在罕见和条件下差异的趋势，这两个参数似乎对ELH以外的任何其他临床上可用的参数有更多的敏感性指标。按订单评估新的电泳参数，但不只是在患者的感官听力损失中，但也在正常情况下-听到主题，我们已经开发了一个特殊的电子设计，用于Tympanic electrocochleography。这一方法被发现比用transtymanic或ear-canal electroes记录更方便，也允许在glycerol脱水试验期间重复测量。The abnormal increase in the AP-latency difference to condensation and rarefaction clicks was found in patients with high-f\hearing·loss as in those with acute low-tone sensorineural hearing loss and with threshold fluctuation。Fur\studies are needed in a larger number of clinical cases before concluding whether such AP-latency difference is caused by ELH.Improvements must also be made on better recording of the low-频率同轴显微镜使用钛电同轴显微镜。

Electrocochleographic indicators potentially available for the evaluation of endolymphatic hydrops (ELH) were studied using experimental animals and clinical materials.Although the enlarged summating potential (SP)/action potential (AP) ratio has been known to be frequently associated with Meniere's disease, this abnormality was found not only in ELH but also in some other inner ear pathological models such as the strial damage due to furosemide. Since the guinea pig ELH model showed a significant decrease in the degree of low-frequency modulation of AP amplitude and the tendency of increase in the AP-latency difference between rarefaction and condensation clicks, these two parameters seemed to be more sensitive indicators for ELH than any other clinically available parameters.In order to evaluate new electrocochleographic parameters not only in patients with sensorineural hearing loss but also in normal-hearing subjects, we have developed a special electrode designed for tympanic electrocochleography. This method is found to be more convenient and less traumatic than recording with a transtympanic or an ear-canal electrodes, even allowing repeated measurements during the glycerol dehydration test. The abnormal increase in the AP-latency difference to condensation and rarefaction clicks was found in patients with high-frequency hearing・loss as well as in those with acute low-tone sensorineural hearing loss and with threshold fluctuation.Further studies are needed in a larger number of clinical cases before concluding whether such AP-latency difference is caused by ELH.Improvements must also be made on better recording of the low-frequency cochlear microphonics using tympanic electrocochleography.