Vascular permeability and regional blood flow in malignant brain tumors

我们在大鼠脑肿瘤模型上观察了颈动脉内注入组胺、前列腺素I2和钙通道阻滞剂对肿瘤内血流的影响。通过氢清除法测量，颈动脉内注入这些物质选择性地增加了肿瘤内的血流量。此外，颈动脉注射组胺增加了大鼠脑瘤模型的瘤内通透性，放射自显影证实了这一点。缓激肽对脑瘤通透性的影响与组胺相同，颈动脉注射缓激肽可增加不同分子大小的肿瘤通透性，从10~3增加到70000。此外，我们还发现这种动脉内给药方法增加了实际的抗肿瘤药物的释放，延长了大鼠脑瘤模型的存活时间。提示该方法可用于脑肿瘤的化疗。

We examined the effects of intracarotid infusion of histamine, prostagrandin I2, and calcium channel blocler on intratumoral blood flow using rat brain tumor model. Intracarotid infusion of these substances selectively increased intratumoral blood flow measured by hydrogen clearance methods. Moreover, intracarotid infusion of histamine increased the intratumoral permeabikity in rat brain tumor model, which was examined by autoradiography. Bradykinin also had a same effect on brain tumor permeanbility as histamine had, and intracarotid bradykinin infusion increased tumor permeability of various molecular size, which was from 103 to 70000. Furthermore, we found this intracaroitd infusion method increased actual antitumor drug delivery, and this method prolonged the survival time of rat brain tumor model. These results suggeted that this intracarotid infusion method can be applied for the brain tumor chemotherapy.