Studies on the biochemical profile of lipid metabolic disorder in cattle

为了研究脂肪牛综合征等肝脏疾病引起的脂质代谢紊乱的生化特征，对牛进行了血液和肝脏检查。对73头临床健康、肝脏无明显病变的牛进行了生化分析，特别是脂质分析。血浆脂质过氧化物、磷脂和胆固醇呈显著相关，说明脂肪酸在含有大量不饱和脂肪酸的磷脂和胆固醇中发生过氧化物。然而，血浆和肝脏脂质过氧化物水平之间没有明显的相关性。牛血浆和肝脏中脂质过氧化物水平分别低于狗和猪。这可能与牛肝脏中脂质过氧化活性较低有关。在44头有肝脏大体病变的健康牛中，观察到血浆脂质成分异常水平，包括脂质过氧化物（9例）、磷脂（8例）和甘油三酯（12例）。对6头脂肪肝牛进行宏观检查，血浆脂质组分中磷脂、游离胆固醇、高密度脂蛋白胆固醇各1例。另一方面，两例脂肪变性患者肝脏脂质成分检查显示肝脏脂质过氧化物和甘油三酯水平异常。

For the biochemical profile of lipid metabolic disorder due to liver diseases like fatty cow syndrome, the blood and liver were examined on cattle.The biochemical analysis especially for lipids was carried out on 73 clinically healthy cattle with no gross liver lesions. The plasma lipid peroxides, phospholipid, and cholesterol were significantly correlated to each other, suggesting that the fatty acids received peroxidation in phospholipid and cholesterol which contain large amounts of unsaturated fatty acids. However, no significant correlation was detected between plasma and liver levels of lipid peroxides. The plasma and liver levels of lipid peroxides in cattle were respectively lower rather than those in dogs and pigs. This might be resulted from the lower activities of lipid peroxidation in bovine liver.In 44 healthy cattle with some gross liver lesions, abnormal levels of plasma lipid components were observed in lipid peroxides(9 cases), phospholipid(8 cases), and triglyceride(12 cases). In 6 cattle with fatty liver by macroscopic examination, abnormal levels of plasma lipid components were detected in 1 case each on phospholipid, free cholesterol, and HDL-cholesterol level. On the other hand, 2 both cases with fatty degeneration examined on liver lipid components revealed to have abnormal levels of liver lipid peroxides and triglyceride.