New Tumor Imaging with porphyrin derivatives which have high tumor-tissue affinity.

自1978年以来，我们小组研究了基于血红蛋白和叶绿素的卟啉衍生物及其金属配合物（共160种），并测试了它们的侧链结构与肿瘤组织积累之间的关系。基于这项研究，我们的团队开始开发新的肿瘤阳性化学物质，用于科学研究，以改善肺癌的诊断和治疗。将新研制的in -111-mono- dtpa -乙二醇- Ga deuterporphyrin（In-111-MDEGD）应用于植入性胰腺癌叙利亚金仓鼠、Lewis肺癌c57黑鼠和人肺腺癌裸鼠，进行肿瘤成像和生物分布检查。在结果数据中，In-111- mdegd显示肿瘤/肺、肿瘤/肾和肿瘤/血比大于Ga-67-citrate。in -111- mdegd在炎症组织中的亲和力远低于Ga-67-citrate。最近，我们还发现了一种新的光敏剂——细菌磷光剂，其最大吸收波长为755nm。

Since 1978,our group has examined porphyrin derivatives based on hemoglobin and chlorophyl and their metal complexes(160 in all) and tested their relationships between side chain structure and tumor tissue accumulation. Based on this research,our group started developing new tumor-positive chemicals for scintigraphic use that would improve the diagnosis and treatment of lung cancers.Recently developed In-111-mono-DTPA-Ethyleneglycol Ga deuterporphyrin(In-111-MDEGD) were applied to Syrian golden hamsters with implanted pancreatic gland cancers,C57-black mice with Lewis lung cancer and nude mice with human lung adenocarcinoma to enable tumor imaging and biodistribution examination.In the resutant data, In-111-MDEGD showed larger tumor/lung,tumor/kidney and tumor/ blood ratio than with Ga-67-citrate. The affinity of In-111-MDEGD in inflammatory tissue was much lower than that of Ga-67-citrate.Recently we also found new photosensitizer-(bacterio-pheophorbide)which has maximum absorbance wavelength at 755nm.