Dental Materials inherited anti-plaque adhesion

The purpose of The investigation is to apply DDS (dilated delivery system) to The dental clinicalmedicine. More than fifty kinds of antiplaque agents and kindred drugswhich chiefly extracted from herbs，were added to the dental materials. the efficacy of eluted drugs confirmed by the bioassay. theresults as follows:1. The effects of adding drugs on The polymers physical properties；药物dissolved readily in the monomers had a tendency to give good physical properties of thepolymers. Flavanone added to MMA和2.6E monomer decreased remarkably the amount of water sorptionof the polymers，whereas increased of polymerized UDMA. To elute the chlorhexidine in distilled water at 37cfor 3 months decreased severely the physical propertieswhereas the flavanone increased them slightly.2. the measurement of the amount of drugs eluted in the amount of drugswater;The chlorhexidine having a concentration of 3% in The polymers eluted 15ug/day per The polymer of0.1g afmersion in the distilled water for 1 month. the Irgasan eluted from the 2.6E polymerThe flavanone effluent of The flavanone was at a concentration of about 2%even after the accelated immersion test in water at 60 - C for 10小时3. Antiplaque effects of thedrugs delivered in water；The chlorhexidine added to The resin in The ratio of 3% inhibited The growth of S.mutans even afterimmersion in water for 7 weeks. The Irgasan at concentration of 10 to 20%不能inhibit Thegrowth of C.albicans after immersion in water for 2 to 6 months，虽然the cells suffered damage partially observed with SEM. the flavanone which was addedat high concentration of 50%，inhibited the growth of s.m otans at the ratio of about 10%. the toxicity of drugs eluted to thehuman tissue cells depended upon the quality, not quantity of drugs。

The purpose of the investigation is to apply DDS (dilated delivery system) to the dental clinical medicine. More than fifty kinds of antiplaque agents and kindred drugs, which chiefly extracted from herbs, were added to the dental materials. The efficacy of eluted drugs were confirmed by the bioassay. The results were as follows:1. The effects of adding drugs on the physical properties of the polymers; Drugs dissolved readily in the monomers had a tendency to give good physical properties of the polymers. Flavanone added to MMA and 2.6E monomer decreased remarkably the amount of water sorption of the polymers, whereas increased that of polymerized UDMA. To elute the chlorhexidine in distilled water at 37゜C for 3 months decreased severely the physical properties, whereas the flavanone increased them slightly.2. The measurement of the amount of drugs eluted in water; The chlorhexidine having a concentration of 3% in the polymers eluted 15ug/day per the polymer of 0.1g after immersion in the distilled water for 1 month. The Irgasan eluted from the 2.6E polymer was much more than that of MMA. The effluent of the flavanone was at a concentration of about 2% even after the accelated immersion test in water at 60゜C for 10 hours.3. Antiplaque effects of the drugs delivered in water; The chlorhexidine added to the resin in the ratio of 3% inhibited the growth of S.mutans even after immersion in water for 7 weeks. The Irgasan at concentration of 10 to 20% could not inhibit the growth of C.albicans after immersion in water for 2 to 6 months, although the cells suffered damage partially were observed with SEM. The flavanone which was added at high concentration of 50%, inhibited the growth of S.mutans at the ratio of about 10%. The toxicity of drugs eluted to the human tissue cells depended upon the quality, not quantity of drugs.