Role of central nervous sytem in the changes in pulmonary hemodynamics and vascular permeability

探讨肺神经支配在肺血流动力学和血管通透性变化中的作用。首先，我们研究了在肺循环和体循环分别灌注的犬双灌注制备中，血流动力学参数变化对支气管-肺吻合口血流的影响。结果表明，交感神经在减少左房压和全身动脉压变化引起的支气管肺吻合口血流变化中起作用。在全身性高血压中，支气管肺吻合口血流受全身动脉压的影响较小，这可能是通过交感神经活动增强以及左房压升高来实现的。有人认为，支气管静脉床受交感神经张力的影响。其次，狗的肺水肿是由注入血清素引起的。特别是5 -羟色胺受体亚型在肺血流动力学变化和肺水肿发展中的作用。结果表明，S_2受体参与了肺血管床的增加，而S_1受体参与了血管通透性的增加。最后，由于已经提出肺神经支配在肺水肿的发展中起作用，因此研究了几种受体拮抗剂在肺水肿发展中的作用。作为一种神经源性肺水肿，我们研究了纤维蛋白诱导的肺水肿。我们研究了几种实验条件对大鼠肺水肿发生率和严重程度的影响。纤维蛋白诱导肺水肿发生率为100%的实验条件如下：腹腔内注射溶液pH 6.5，迷走神经切开术。在此实验条件下，我们发现自由基清除剂抗组胺、乙酰胆碱和皮质类固醇均不能阻止水肿的形成。少

Roles of pulmonary innervation in the changes in pulmonary hemodynamics and vascular permeability were investigated. First, we studied the effects of changes in hemodynamic parameters on the bronchopulmonary anastomotic blood flow, in a canine dual perfusion preparation in which the pulmonary and systemic circulations were separately perfused. Obtained results indicated that the sympathetic nerves play a role in reducing the changes in the bronchopulmonary anastomotic blood flow caused by a change in left atrial pressure and systemic arterial pressure. In systemic hypertension, it is likely that the bronchopulmonary anastomotic blood flow is less affected by the systemic arterial pressure, via an enhanced sympathetic nervous activity as weel as via a rise in left atrial pressure. It has been suggested that the bronchial venous bed is affected by the sympathetic nervous tone. Secondly, pulmonary edema was caused by infusing serotonin, in dogs. Especially the serotonin receptor subtypes … More were evaluated in terms of the roles in the changes in pulmonary hemodynamics and development of pulmonary edema. It was suggested that S_2 receptor participated in a rise in pulmonary vascular beds, whereas S_1 receptor participated in an increase in vascular permeability.Last, since it has been suggested that lung innervation play a role in the development of pulmonary edema, effects of several receptor antagonists in the development of pulmonary edema were investigated. As a neurogenic pulmonary edema, we studied the fibrin-induced pulmonary edema. We examined the effects of several experimental conditions on the incidence and severity of pulmonary edema in rats. An experimental condition where the fibrin-induced pulmonary edema happens at a rate of 100 %, was found to be as follows; 6.5 of pH in solution injected intracisternally and vagotomy. By using such an experimental condition, we fount that neither radical scavenger anti-histamine and acetylcholine nor corticosteroid prevented the edema formation. Less