Studies on increasing sensitivities in pulpal inflammatory reactions by new inflammatory mediator(PAF)

有些兴奋剂很容易引起牙髓组织的炎症反应。我们已经报道了在牙髓中检测到组胺和其他炎症介质，它们可能在炎症过程中起作用。拥堵。研究了一种新的炎症介质，在牙髓炎症中的意义。大鼠牙髓组织中检测到PAF。PAF刺激大鼠牙髓组织PGI_2>TXA_2释放。这一事实表明内皮细胞起着重要的作用。在动脉平滑肌中，PAF增强了对肾上腺素的收缩反应。在其他平滑肌中没有发现这种增强。在神经炎症（坐骨神经的互反电刺激实验）中，PAF没有增强反应，在内皮细胞存在的情况下，它增加了毛细血管的通透性。在体内神经肌肉制备中，paf预处理可以抑制抗结核药物的松弛作用，这一事实也支持了这一点。在肺呼吸阻力实验中，抗PAF药物、抗过敏剂及B_1相关化合物均可拮抗PAF所致气管收缩的增加。然而，血小板聚集活性不受这些拮抗剂的影响。因此，上述结果提示，在牙髓组织的初始炎症过程中，PAF可能在炎症条件的形成中起到了预先安排的作用，并且PAF诱导的条件可能会非常强化介质的释放和作用。

Some stimulants evoke easily an inflammatory reactionin the pulp tissue. We have reported that histamine and other inflammatory muediators were detected in the pulp and that may be play a role in the inflammatory process. PAF. a new inflammatory mediator, was studied on the signification in pulpal inflammation.1. PAF was detected in pulpal tissue of rats. And PAF stimulated PGI_2>TXA_2 release from rat pulppal tissue. The fact suggests that the endothelial celles play a important role.2. In the arterial smooth muscle, PAF potentiated the contracted reaction toadrenaline. The potentiation was not found in other smooth muscles.3. In neuronal inflammation ( reciprocal electrical stimulation experiments in the sciatic nerve), PAF did not potentiate the reaction, and it increased thecapillary permeability under the existence of endothelial cells. This also is supported by the fact that in the in vivo nerve-muscle preparation, the relaxant action to anticurare agents is inhibited by pretreatment of PAF.4. In pulmonary respirationresistance experiments, the increase of tracheal contraction with PAF was antagonized by anti-PAF drugs, and also anti- allergic agents and B_1 related compounds. The pulatelet aggregating activity, howoevor, did not be influenced by theseantagonists. Therefore, the above mentionned results suggest that in the initial inflammatory process in the pulpal tissue, PAF may be play a role of the formation of the prearrangements of inflammatory conditions and that the PAF -induced condition may be very intensify the release and actions of mediators.