Experimental studies in rabbit's aneurysmal model using argon laser - formation, growth, rupture and therapy -

用戊巴比妥麻醉20只体重3 - 5 Kg的日本白色家兔。经双侧股动脉将3根导管（血管镜、球囊导管和氩激光探头）插入主动脉。在胸主动脉处充盈球囊导管，血流停止。在血管镜下用氩激光热头以30焦耳的能量汽化腹壁。术后给予高血压食物和药物喂养，8只兔于术后2天内因主动脉穿孔死亡。12只家兔存活2 ~ 4周。在此期间，证实了3例动脉瘤（15%）。组织学检查显示主动脉内壁出现环形山。火山口的底部已经部分向外突出，并再次内皮化。血栓形成、生长和破裂的因素与激光照射的焦耳数、血流动力学应力及其持续时间有关。

Twenty Japanese white rabbits that weighted 3 to 5 Kg were anesthetized with Nembutal. 3 catheters (angioscope, balloon catheter and argon laser's probe) were inserted to aorta using bilateral femoral arteries. The balloon catheter was inflated at the thoracic aorta and the blood stream was stopped. Under angioscope, abdominal wall were vaporized with 30 joules using the hot tip of argon laser. After this procedures, the rabbits were fed with hypertensive food and drugs.Eight rabbits died within 2 days after surgery because of perforation of aorta. Twelve rabbits were survived from 2 to 4 weeks. During this time, 3 aneurysms (15%) were confirmed. In histological examinations, the irradiated inner wall of aorta showed the crater. The floor of the crater had become partially protruded outside and endothelialized again. And its surface were created by on organized thrombus.The factors in aneurysmal formation, growth and rupture were confirmed to be concerned with the joule of laser irradiation, hemodynamic stress and its duration.