Study on Early Pathology of Senile Disciform Macular Degeneration using a computerized image-processing system

为了获得眼底后极年龄相关病变早期诊断的更详细信息，将图像处理程序应用于61名50岁以上患者的荧光素血管造影照片：38例新生血管型年龄相关性黄斑变性ARMD患者（老年性黄斑变性SDMD）和23例无脉络膜新生血管的ARMD患者。对于增强对比度的图像处理，应用了使用局部范围修改的空间变化对比度增强，在增强的血管造影片上显示出比常规血管造影片更多的玻璃疣，使得可以观察到更小的玻璃疣，并使低质量的血管造影片具有更高的分辨率。在一些患者中，可观察到广泛分散的点状或颗粒状高荧光。这种强荧光可能代表弥漫性玻璃疣（绿色，W.R.）或基底层状沉积物（Sarks，S.）。在增强的血管造影片上，一些软性玻璃疣的强荧光缺乏均匀性。

In order to obtain more detailed information for early stage diagnosis of age- related pathologies at the posterior pole of the eye- ground, an image processing procedure was applied to fluorescein angiographs from 61 patients over 50 years of age : 38 patients with the neovascular type of age-related macular degeneration ARMD (senile disciform macular degeneration SDMD) and 23 patients with ARMD without choroidal neovascularization. For the image processing to enhance contrast, spatially - variant contrast enhancement using local range modification was applied.On the enhanced angiographs larger numbers of drusen were demonstrated than on the regular angiographs, making smaller drusen observable and giving the angiographs of low quality higher resolution. In some patients, widely scattered dot or granular hyperfluorescence became observable. This hyperfluorescence might represent diffuse drusen (Green, W.R.) or basal laminar deposits (Sarks, S.). On the enhanced angiographs some soft drusen came to show lack of uniformity in their hyperfluorescence.