Prevention of mother-to-child transmisson of HTLV-1

预防HTLV-1的母婴传播。人类嗜t淋巴病毒I型（HTLV-1）与成人t细胞白血病（ATL）、热带痉挛性麻痹/HTLV-1相关脊髓病（TSP/HAM）和HTLV-1相关视网膜病（HAR）等严重疾病密切相关。不幸的是，目前还不可能治疗这些疾病。预防这些疾病的唯一可行方法是打破HTLV-1病毒的恶性循环。HTLV-1在长崎严重流行。长崎孕妇中带菌者的患病率约为4%。已确定HTLV-1的主要传播途径是母体，特别是通过母乳传播。孕产妇传播的发生率为20-30%。母体传播显著降低至配方奶喂养3%的水平。大约90%的产妇感染是通过不给带菌母亲喂奶而被阻断的。6月以上母乳喂养组感染发生率为16.2%，6月以下母乳喂养组感染发生率为10.4%，配方奶喂养组感染发生率为2.7%。比较长期母乳喂养组和短期母乳喂养组，我发现他们之间没有任何区别。

Prevention of mother-to-child transmission of HTLV-1.Human T-lymphotropic virus type I (HTLV-1) is closely linked with serious diseases, such as adult T-cell leukemia (ATL), tropical spastic pararesis/HTLV-1 associated myelopathy (TSP/HAM) and HTLV-1 assosiated retinophathy (HAR). Unfortunately, it is not currently possible to care the diseases. The only way aviable to provent thease diseases is breaking the cycle of HTLV-1 endemy.HTLV-1 is heavily endemic in Nagasaki. The prevelance of carriers in Nagasaki is approximately 4% in pregnant women.The main route of HTLV-1 transmission has been established as maternal, specifically via breast milk. The incidence of maternal transmission is 20-30%. Maternal transmission were remearkably decreased to the level of 3% in formula-fed.Approximately 90% of maternal infection was blocked by refraining of breast feeding by carrier mothers.The incidence of infection in group of breast-fed over 6 month was 16.2%, under 6 month was 10.4% and in the group of formula-fed was 2.7%.Comparing the long term breast-fed group and the short term-breast-fed group, I can't find any differene between them.