A study of the effectiveness of a carcinostatic and increasing carcinostatic tolerance

一项关于抑癌和增加抑癌耐受性的效力的研究该研究的概要（上一财政年度）该研究的目的有三个方面：制备一种抗体给予抗-carcinostatica抗体）以减轻抑癌的副作用b）分析抑癌的增强作用制备一种抗-carcinostatica单克隆抗体在该财政年度，作者集中于分析与抑癌相关的副作用的减轻。effect3.to anti-carcinostatic2.to 1.to两组Wistar大鼠用于实验。一组单纯给予ADM，另一组给予ADM后加用抗ADM抗体，比较两组心脏和骨髓功能的变化。ADM加抗体组的心脏功能障碍减少，骨髓研究显示白细胞和血小板水平保持不变。观察到抑癌相关副作用的显著缓解。 ...更多信息 目的是确定抗癌抗体的正确剂量和最佳给药时间。(The在该实验中，在抑癌剂后90分钟施用抗体）。我们也希望能制备出单克隆抗体和其他抗癌药物的抗体，并检测抗癌药物的有效性和耐受性。目前还没有一种有效的媒介来增加对抑癌药物的耐受性。短时间间隔重复施用抑癌剂是获得耐受性合理增加的最理想方法。实现这种重复给药的一种方法是中和药物的作用，这将允许减轻副作用。因此，我们可以增加药物的有效性。阿霉素联合抗体组的抗肿瘤效果比单纯阿霉素组更明显。作者成功地获得了一株IgG型单克隆抗体，该单克隆抗体对ADM具有特异性反应，其特异性应高于以往使用的多克隆抗体，下一步的实验将集中于提高新抗体的特异性。少

A STUDY OF THE EFFECTIVENESS OF A CARCINOSTATIC AND INCREASING CARCINOSTATIC TOLERANCESummary of the study(for the past fiscal year)The purpose of the study was threefold :1.to prepare an antibody anti-carcinostatic2.to administer the antibody anti-carcinostatica)to relieve side effects of the carcinostaticb)to analyze the potentiation of the carcinostatic effect3.to prepare a carcinostatic monoclonal antibodyOver the fiscal year, the author concentrated on analyzing the alleviation of carcinostatic related side effects. Two groups of Wistar rats were used for the experiment. One group received ADM only, while the other received ADM followed by an antibody anti-ADM, Heart and bone marrow functions in these two groups were then analyzed and compared. Heart functional disorders in the ADM plus antibody group were reduced, and the bone marrow study showed that leukocyte and thrombocyte levels remained unchanged. Significant easing of carcinostatic-related side effects was observed.The nex … More t objective will be to determine the correct dosage of the antibody anti-carcinostatic and the optimal timing for administration. (The antibody was administered 90 minutes after the carcinostatic in this experiment). We also hope to prepare a MoAb and antibodies for other carcinostatics.We then examined the effectiveness and tolerance levels of a carcinostatic. There is not yet an effective medium for increasing tolerance to carcinostatic drugs. Repeated administration of the carcinostatic at short intervals is the most desirable means of obtaining reasonable increases in tolerance. One way to achieve such repeated administration would be to neutralize the drug's effects, which would allow side effects to be relieved. Thus, we can increase the effectiveness of the drug. Indeed, a more significant anti-cancer effect was observed in the ADM plus antibody group the ADM-alone group.Finally, a monoclonal antibody was prepared. The author succeeded in obtaining an IgG-type monoclonal antibody which has a specific reaction against the antigen, ADM.This monoclonal antibody should be more specific than polyclonal antibodies used in the past, and the next experiments will focus on increasing the specificity of the new antibody. Less