Pathological differences in oseoporosis following menopause or oophorectomy

分析绝经后骨质疏松症与卵巢切除术后骨质疏松症的病理学差异。对绝经或卵巢切除后平均3年的受试者进行了研究。绝经后受试者的雄烯二酮和雌激素水平明显高于卵巢切除者。然而，绝经期受试者的类固醇优势并没有反映在骨代谢中。两个受试者组之间通过任何测定方法（MD、QCT、DPA、DXA）或任何测量部位（外周骨/中轴骨、横骨/皮质骨）检测到BMD无显著性差异。因此，临床上认为与卵巢切除相关的骨质疏松症，引起骨的剧烈变化，与绝经后的生理现象骨质疏松症相当。然而，绝经期妇女的临床异质性可能掩盖了绝经和卵巢切除后骨反应的个体差异。因此，体外研究是必要的，虽然只有初步的结果，我们已经注意到定量和定性的差异，骨髓细胞卵巢切除术的反应。这些发现将在未来的研究中得到进一步的研究。

Enodocinological dynamics, bone metabolism and bone mineral density (BMD) were and analyzed to study whether or not there aer pathological differences in osteoporosis following menopause and that following oophorectomy. Subjects in whom a mean period of 3 years had passed since menopause or oophorectomy, a time when effects on vone metabolism should be evident, were studied, Levels of androstenedione and e_1, considered to have a fanorable effect on bone matabolism, were significantly higher in menopausal subjects compared with subjects undergoing oopherectomy. Howeever, steroid dominance in the menopausal subjects was not reflected in bone metabolism. Nosignificant dirrerence in BMD was detected between the two subject groups by any determination method (MD, QCT, DPA, DXA) or for any site measured (peripheral bone/axial bone, travecular bone/cortical bone). Therefore, osteoporesis associated with oophorectomy, causing drastic changes in bone, ws clinically considered to be comparable to osteoporosis associated with the physiological phenomenon if menopause. However, clinical heterogeneity in junan subjects may mask fine individual differences in the response of bone to menopause and oophorectomy. Invitro research is therefore necessary, Although only preliminary results are available, we have noted quantitative and qualitative differnces in the response of bone marrow cells to oophorectomy. These findings will be followed up by future reseatch.