Effect of Pathogen Status on the Manifestation of Accelerated Senescence and Murine Senile Amyloidosis in Senescence Accelerated Mouse (SAM)

我们研究了病原体状态对加速衰老和小鼠老年性淀粉样变性(AApoAII淀粉样变性)表现的影响，使用2-11个月龄的SAMPX在常规和无特定病原体(SPF)条件下保持。与常规组相比，SPF组与常规组相比，与年龄相关的加速衰老表现(通过分级评分系统衡量)显著受到抑制。男性组衰老加速的表现明显高于女性组。在6个月龄的常规组，33%的小鼠出现了轻度的胃肠道ApoAII淀粉样变性。在11个月龄的常规组，100%的小鼠观察到全身性ApoAII淀粉样变性，累及脾和肝脏。然而，在SPF组，在任何年龄的小鼠中都没有观察到ApoAII淀粉样变性。因此，环境因素在加速感觉和ApoAII淀粉样变性的发病机制中起着关键作用。

We investigated the effect of pathogen status on the manifestation of accelerated senescence and murine senile amyloidosis (AApoAII amyloidosis) , using 2 to 11-month-old SAMPX maintained both in conventional and in specific pathogen free (SPF) conditions. Age-related manifestation of accelerated senescence as measured by the grading score system, was significantly suppressed in the SPF group as compared to the conventional group. Manifestation of accelerated senescence was significantly higher in the male group than in the female group. In the 6-month-old conventional group, mild gastrointestinal AApoAII amyloidosis was observed in 33% of mice. In the 11-month-old conventional group, systemic AApoAII amyloidosis involving the spleen and liver was observed in 100% of mice. However, in the SPF group, no AApoAII amyloidosis was observed in any age of mice. Thus, the environmental factors are critical in the pathogenesis of accelerated senscence and AApoAII amyloidosis.