Development of Selective Flow Reactions using Immobilized Organoaluminum Reagents Possessing Molecular Recognition Ability

本研究计画系利用具有分子辨识能力之固定化有机铝试剂，发展选择性流动反应。开发可应用于有机铝试剂的流动合成应用的选择性反应。(1)环氧化合物的连续重排-Tishchenko反应的研究修饰的有机铝试剂可成功地用作烷基取代氧化苯乙烯的连续重排和Tishchenko二聚反应的活性催化剂。(2)各种醛类化合物的Tishchenko反应的研究改性有机铝试剂与某些环氧化物如反式氧化二苯乙烯的组合适合作为芳香醛和脂肪醛的Tishchenko反应的有效催化剂。(3)环氧树脂的合成应用研究在改性有机铝催化剂的作用下，将desbeta，gamma-环氧醛转化为不饱和甲酸酯.具有分子识别能力的固定化有机铝试剂的流动反应研究（1）流动法中烷基取代氧化苯乙烯的连续重排-Tishchenko反应研究烷基取代氧化苯乙烯的连续重排和Tishchenko二聚反应在室温下，在固定的、不溶的聚合有机铝试剂上以低选择性得到了所需的酯。

This research project has been performed to develop selective flow reactions using immobilized organoaluminum reagents possessing molecular recognition ability as disclosed in the following points :1. Development of selective reactions capable of applying for flow synthetic application using organoaluminum reagents.(1) Study of sequential rearrangement-Tishchenko reaction of epoxidesModified organoaluminum reagent can be successfully utilized as an active catalyst for the consecutive rearrangement and Tishchenko dimerization of alkyl-substituted stirene oxides.(2) Study of Tishchenko reaction of various aldehydesThe combination of the modified organoaluminum reagent with a certain epoxides such as trans-stilbene oxide are suitable as effecting catalysts for the Tishchenko reaction of aromatic and aliphatic aldehydes.(3) Study of synthetic application of epoxyaldehydesbeta, gamma-epoxyaldehyde has been converted into unsaturated formates with the modified organoaluminum catalyst.2. Study of flow reaction using immobilized organoaluminum reagent possessing molecular recognition ability(1) Study of sequential rearrangement-Tishchenko reaction of alkyl-substituted stirene oxides in flow methodThe consecutive rearrangement and Tishchenko dimerization of alkyl-substituted stirene oxides has afforded the desired ester in low selectivity on stationary, insolubilized polymeric organoaluminum reagent at room temperature.