Anti-inflammatory effct of eicosatrienoic acid

二十碳三烯酸（ETrA）是花生四烯酸的n-9同源物，通常在组织中含量很低。ETrA可以被纳入细胞膜，并可能竞争进入类二十烷形成酶。在本研究中，我们在大鼠的白细胞中测量了膳食中ETrA的掺入。还考察了饲料中亚油酸的影响。ETrA被有效地纳入腹膜渗出细胞（PEG）， PEC中磷脂总脂肪酸含量高达10%，无饱和现象。饲粮LA水平高于需要量时，积累效率显著降低。体外刺激后，ETrA积累与PEG减少LTB4合成相关。这种作用是由于LTA4水解酶的抑制作用。因此，饮食中的ETrA可以调节炎性类二十烷酸的合成。这一发现为进一步研究膳食ETrA的生化和抗炎作用提供了依据。

Eicosatrienoic acid (ETrA) is the n-9 homologue of arachidonic acid and normally found in tissues at very low levels. ETrA can be incorporated into cell membranes and may compete for access to eicosanoid forming enzymes. In the present study, incorporation of dietary ETrA into leukocytes was measured in rats. The influence of dietary linoleic acid was also checked. ETrA was efficiently incorporated into peritoneal exudate cells (PEG)up to 10% of total fatty acids in phospholipids in PEC without saturation phenomenon. The efficiency of accumulation was reduced significantly by increasing dietaly LA levels above essential requirements. ETrA accumulation correlated with reduced LTB4 synthesis by PEG following stimulation in vitro. This effect was attributable to inhibition of LTA4 hydrolase. Thus, dietaly ETrA can modulate inflammatory eicosanoid synthesis. The findings juslify further studies into the biochemical and anti- inflammatory effects of dietary ETrA.