Dynamic intravenous coronary arteriography by using synchrotion radiation and its application to measuring coronary blood flow

我们利用同步辐射二维X射线束进行了动态静脉冠状动脉造影（CAG）。我们在10只狗和1只山羊的静脉内进行了动态冠状动脉造影，使用的是由硅晶体的同步辐射的不对称反射产生的强单色（33.3KeV）的二维X射线束。通过插入下腔静脉的导管注射造影剂，并用X射线束照射受试者。用电视摄像机获取图像，并记录在录像带上（33幅图像/秒）。在狗中，我们通过应用渡越时间分析从CAG图像估计左前降支冠状动脉（LAD）的血流量。6只犬行开胸手术，用电磁流量探头测量其LAD流量。在4只狗中，血管周围多普勒 ...更多信息 在静脉CAG前几周植入的血流探头用于测量LAD流速。利用同步辐射二维X射线束在犬和山羊体内进行了动态冠状动脉造影。动态静脉内CAG图像清晰可见，即使是有意创建的冠状动脉狭窄约1 mm长。此外，冠状动脉血流量可以估计从动态CAG图像具有可接受的准确度。由静脉CAG计算的LAD流量为14.7（[SY. ±.]）5.1ml/min，而用电磁流量计或超声流量计测得的LAD流量为16.6（SY. ±.）结果表明，同步辐射动态静脉冠状动脉造影（DCAG）可同时评价冠状动脉的解剖结构和血流，具有微创性。临床应用此术式是可行的。少

We have developed dynamic intravenous coronary arteriography (CAG) by using a two-dimensional X-ray beam from synchrotron radiation. We investigated the ability of dynamic intravenous CAG images to visualize the coronary arteries and to estimate coronary blood flow in animals.We performed intravenous CAG in 10 dogs and one goat by using an intense, monochromatic (33.3KeV), two-dimensional X-ray beam, that was generated by asymmetrical reflection of synchrotron radiation from a silicon crystal. A contrast agent was injected through a catheter inserted into the inferior vena cava and the subject was irradiated with the X-ray beam. Images were obtained with a TV camera and were recorded on videotapes (33 images/sec).In the dogs, we estimated blood flow in the left anterior descending coronary artery (LAD) from the CAG images by applying a transit-time analysis. Six dogs underwent thoracotomy and their LAD flow was measured with an electromagnetic flow probe. In 4 dogs, a perivascular Dopp … More ler flow probe that had been implanted a few weeks before the intravenous CAG was used to measure LAD flow velocity. Estimated LAD flow was compared with LAD flow actually measured.The two-dimensional X-ray beam from synchrotron radiation permitted us to achieve dynamic intravenous CAG in the dogs and goat. Dynamic intravenous CAG images visualized clearly even an intentionally created coronary stenosis about 1 mm in length. In addition, coronary blood flow could be estimated from the dynamic CAG images with an acceptable degree of accuracy. LAD flow calculated from intravenous CAG was 14.7(]SY.+-.])5.1ml/min, whereas LAD flow measured with an electromagnetic flowmeter or ultrasound flowmeter was 16.6(]SY.+-.])4.8ml/min. There was a close correlation between the estimated and measured LAD flows (r=0.92, p<0.001).Thus, dynamic intravenous CAG using synchrotron radiation is minimally invasive and permits the simultaneous evaluation of coronary anatomy and coronary blood flow. Clinical application of this procedure seems to be feasible. Less