The Study in the Effect of Oriental Medicines on Sexual Function and Testis Function -Especially about Jashoshi-

目前，还没有一种药物对勃起功能障碍有效。我们一直在尝试用新技术开发对勃起功能障碍有效的药物。Jashoshi是一种东方药物，自古以来就被认为对勃起功能障碍有效。我们对其药物作用进行了研究，得到了以下结果：正常小鼠和实验性隐睾小鼠口服甲舒舒可引起以下反应：1. 增加了挂载次数，缩短了挂载延迟。2. 其趋势是血清睾酮浓度升高。3. 雄激素靶器官之一的下颌骨腺胰蛋白酶样蛋白酶活性升高。电泳酶谱分析与睾酮给药相同。4. 颌下腺表皮生长因子M-RNA表达增强，与睾酮组相同。然而，给药对去势小鼠无影响，各组小鼠血清LH和FSH浓度均不受影响。这些结果表明，Jahshoshi增加了小鼠的性行为和血清睾酮浓度。另一个可能是其中一个的机制。血清黄体生成素和卵泡刺激素浓度未见变化，提示佳舒对睾丸有直接作用。

At present, there is no medicine which is effective in erectile dysfunction. We have been trying to develope with new techniques medicines which are effective in erectile dysfunction. Jashoshi is one of the oriental medicines which have been said to be effective in erectile dysfunction from ancient times. We have investigated its medicinal action, and obtained following results. Oral administration of Jashoshi in normal and experimentally cryptorchid mice caused the following things. 1. The number of times of mount was increased and the mount latency was shortened. 2. The tendency was toward higher serum testosterone concentrations. 3. Trypsin-like protease activity of the submaxillary gland, which is one of the target organs of androgen in mice, was increased. Zymogramatic analysis in electrophoresis was the same as in testosterone administration. 4. M-RNA expression of epidermal growth factor in the submaxillary gland was enhaned, which was the same as in testosterone administration. However, there were no changes in castrated mice by Jashoshi administration, and in all groups of mice, seurm LH and FSH concentrations were not affected by Jashoshi administration. These results indicate that Jahshoshi increases mice sexual behavior and serum testosterone concentration. And presumably the other is the mechanism involved of one. No changes in serum LH and FSH concentrations suggest that Jashoshi has direct actions on testes.