A study of effects of fluoride-releasing resin sealants on caries prevntion

本研究旨在探讨实验性树脂封闭剂的氟释放行为、封闭剂下氟吸收以及封闭剂周围氟吸收的变化.振荡1 d的样品氟释放速率是对照值的3倍，不振荡1 d的样品氟释放速率是对照值的1.8倍，在去离子水、磷酸盐缓冲液和人工唾液中的样品氟释放量或释放速率存在显著差异.基质树脂的吸水率与氟的释放速率相关，氟的释放量随着吸水率的增加而增加。DPHA*、DPHA/3G、2.6E/HEMA、2.6E/3G、HD依次降低.具有优异PMF溶解性的基质树脂是由A液：DPHA* 和B液：EMA/1G（75：25）+PMF 40（30%）组成的No.10和由A液：DPHA* 和B液：EMA/1G（75：25）组成的No.12。25）+PMF 60（15%）的树脂封闭剂中氟的释放量较大，为对照组的1.7 ~ 1.9倍.实验组牙釉质在4周后吸收的氟离子浓度高于对照组，无论是直接在封闭剂下方还是在封闭剂周围。此外，实验封闭剂周围区域的釉质吸收的氟离子的深度大于对照组。

This study was undertaken to investigate the fluoride releasing behavior of experimental resin sealants, fluoride uptake directly under the sealant as well as in the area surrounding the sealants after application of the fluoride releasing sealants to the bovine enamel.1. The rate of fluoride release from samples that were shaken was three times that of control values for one day and 1.8 times that after one day without shaking.There was significant difference in the amount or rate of fluoride release among samples stored in deionized water, phosphate buffer solution or artificial saliva.2. The water sorption of matrix resin and the rate of fluoride release were correlated and the amount of fluoride release progressively increased with increases in water sorption. The order of decrease was DPHA*, DPHA/3G,2.6E/HEMA,2.6E/3G,HD.3. Matrix resins with excellent solubility of PMF were No.10, which consisted of A liquid : DPHA* and B liquid : EMA/1G (75 : 25) +PMF 40 (30%), and No.12, which consisted of A luquid : DPHA* and B luquid : EMA/1G (75 : 25) +PMF60 (15%).The amount of fluoride released from those resin sealants was greater, ranging from 1.7 to 1.9 times that in the control group.4. The concentration of fluoride ions taken up by the bovine enamel after four weeks in samples coated with the experimental group was higher then that in the control group both directly under the sealant and in the area surrounding the sealant. Also, the depth of fluoride ion taken up by the enamel in the area surrounding the experimental sealant was greater than that in the control group.