Membrane filtration of macromolecular substances: Measurement and Modelling on the micro- and macro-scales

关于过滤过程中结构和流动的空间和时间分辨MRI数据（MRI：磁共振成像）的建模将导致对中空纤维膜中大分子过滤过程的深入了解。整体工艺参数也在微观尺度上决定过滤过程-除了微观上的空间变化参数（如膜特性和待过滤的物质）之外。该提案的重点是适当的测量协议和过滤模型的问题，探索沉积物的物理化学性质，分散系数，混合和可逆性。在中空纤维膜过滤过程中，将测量大分子溶液的结构图像和流动。速度场将与沉积物及其几何形状以及潜在的空间变化粘度相关。色散系数将在空间上进行测量。在过滤过程中，这些量的系统原位测量将与宏观量的测量相结合。这将是进一步发展过滤模型的基础。重点将是结合联合收割机微观和宏观参数，为不同长度尺度上的过滤过程建模。

Modelling of spatially and time resolved MRI data (MRI: magnetic resonance imaging) regarding structure and flow during filtration will lead to an in-depth understanding of filtration processes of macromolecules in hollow fiber membranes. Integral process parameters determine the filtration processes also on the microscopic scale – in addition to microscopically, spatially varying parameters like membrane properties and substances to be filtrated. The proposal focuses on questions of appropriate measurement protocols and on filtration modelling exploring the physicochemical properties of deposits, the dispersion coefficients, mixing and reversibility.Structural images and flow of macromolecular solutions will be measured during filtration in hollow fiber membranes. Velocity fields will be correlated with the deposits and their geometry as well as with a potentially spatially varying viscosity. Dispersion coefficients will be measured spatially resolved. A systematic in situ measurement of these quantities during filtration will be combined with the measurement of macroscopic quantities. This will be the basis for further development on filtration models. The focus will be to combine microscopic and macroscopic parameters for modelling the filtration processes on different length scales.