Optical-molecular cooperative computing based on parallel optical trapping technique

本研究旨在发展光分子协同计算技术，该技术基于对具有光场分布的一组分子的操纵。主要的研究目标包括设计一种有效的计算算法，建立一种通过平行光学捕获来操纵附着在微珠上的DNA分子的方法，开发一种在局部空间内进行DNA反应的光子方法，并展示这些光子技术在DNA记忆中的可用性。对信息密度、处理时间和数据传输速率的数值计算结果解释了基于光分子协同计算的信息系统的基本特征。通过数学分析和DNA计算，我们创建了一个有效的离散二次规划算法。使用VCSEL阵列源的平行光学捕获技术用于处理DNA分子群的位置…更多地附着在头（DNA簇）上。实验结果表明，该方法适用于在不发生机械运动的情况下，通过发射源的顺序切换实现DNA簇的并行转移，也适用于5个DNA簇的堆叠。此外，还开发了一种用于DNA反应的光子方法；该方法利用光热转换引起的DNA溶液中温度的局部变化。一个重要的成就是杂交和变性DNA在一个头或衬底上成功地控制与聚焦激光束照射。测定最小反应宽度为5微米。我们提出了光子DNA记忆，其中包含发夹DNA的系统被使用并通过光子技术操作。实验结果表明，例如，通过适当的时间调制辐照光束的功率，可以在头部上重复操作数据DNA的附着和分离。我们还成功地将数据DNA从一个底物读取到一个局部的头部。少

This study is aimed at developing optical-molecular cooperative computing techniques, which are based on manipulation of a group of molecules with optical field distributions. The major research targets include devising an effective computing algorithm, establishing a method for manipulating DNA molecules that are attached to microscopic beads by parallel optical trapping, developing a photonic method for DNA reactions within a local space, and demonstrating the usability of these photonic techniques in DNA memory.The result of numerical calculations concerning information density, processing time, and data-transferring rate explains fundamental characteristics of an information system based on optical -molecular cooperative computing. We have created an efficient algorithm for discrete quadratic programming via mathematical analyses and computation with DNA.The parallel optical trapping technique using VCSEL array sources were used for handling the position of groups of DNA molecules … More attached to a bead (a DNA cluster). Experimental results demonstrate that the method is applicable in transferring DNA clusters in parallel by sequential switching of emitting sources without any mechanical movement, and in stacking five DNA clusters. In addition, a photonic method was developed for DNA reactions ; the method utilizes local change of the temperature in a DNA solution induced by photo-thermal conversion. An important achievement is that hybridization and denaturation of DNA on a bead or a substrate are successfully controlled by irradiating with a focused laser beam. The minimum reaction width was measured as 5 micrometer.We proposed photonic DNA memory, in which a system containing hairpin DNA is used and operated by photonic techniques. Experimental results demonstrate that, for example repeating operations of attachment and detachment of data DNA on a bead is possible by appropriate temporal modulation of the power of the irradiation beam. We also succeeded in reading data DNA out from a substrate to a bead locally. Less