Identification of genes responsible for Down syndrome using mice harboring a human artfuciak chromosome (HAC).

在这项研究中，我们试图建立新的唐氏综合征模型小鼠。因此，我们利用了十多年来积累的人类21号染色体基因图谱、细菌人工染色体（BAC）克隆和最近发展起来的人类人工染色体（HAC）。

In this study, we attempted to produce novel Down syndrome model mice. We therefore took advantage of gene map of human chromosome 21 which we have brushed up over a decade, bacterial artificial chromosome (BAC) clones, and human artificial chromosome (HAC) which has been developed recently.