Glucose- and temperature- dependent regulation of spontaneous firing in SNr GABAergic neurons

目前尚不清楚SNr gaba能神经元持续高频自发放电的调控机制。研究了急性解离SNr gaba能神经元自发放电的葡萄糖和温度依赖性调节。急性解离gaba能神经元自发放电的葡萄糖和温度依赖性调节与急性脑切片细胞外记录的结果不同（Yuan， H. et al, Neurosci Lett 2004）。这些结果表明，脑内SNr gaba能神经元的自发放电可能受到神经元周围环境的调节。

It has not been identified that regulatory mechanisms of persistent high frequency spontaneous firing in SNr GABAergic neuron. Glucose- and temperature- dependent regulation of spontaneous firing in acutely dissociated SNr GABAergic neuron was investigated. Glucose- and temperature- dependent regulation of spontaneous firing in acutely dissociated GABAergic neuron was distinct from the results of the extracellular recording in acute brain slices (Yuan, H. et al, Neurosci Lett 2004). These results suggest that the spontaneous firing in SNr GABAergic neuron could be regulated by the environment around a neuron in brain.