Novel treatment strategy of type 2 diabetes focused on beta cell mass

我们研究了葡糖激活剂(GKA)对β细胞功能和增殖的影响。GKA激活GKA可增加IRS-2和细胞周期信号分子的表达水平。GKA能够在不依赖胰岛素刺激的情况下刺激β细胞增殖，并在不依赖IRS-2的情况下刺激β细胞功能。此外，我们的结果增加了GKA在过度氧化应激下在β细胞中不能很好发挥作用的可能性。

We investigated the effect of glucokinase activator (GKA) on beta cell function and proliferation. Glucokinase activation by GKA increased expression levels of IRS-2 and cell cycle signaling molecules. GKA was able to stimulate beta cell proliferation independently of insulin stimulation and stimulate beta cell function independently of IRS-2. Also, our results raise the possibility that GKA do not work well under excessive oxidative stress in beta cells.