Elucidation of the mechanism of immunosuppression by mesenchymal stem cells in cancer microenvironments

在这项研究中，我们评估了间充质干细胞（MSC）在癌症微环境中的免疫学作用。GFP嵌合小鼠模型显示骨髓来源的间充质干细胞向癌组织迁移并增强肿瘤生长。人间充质干细胞通过产生多种免疫抑制细胞因子如il - 6和VEGF来抑制树突状细胞的功能。这些结果表明，间充质干细胞在癌症微环境中诱导癌症免疫逃逸，可能是恢复癌症患者免疫能力的一个有吸引力的靶点。

In this study, we evaluated the immunological roles of mesenchymal stem cells (MSC) in cancer microenvironment. GFP chimeric mouse models showed that bone marrow-derived MSC migrated to caner tissues and augmented the tumor growth. Human MSC inhibited dendritic cells functions through the production of a variety of immunosuppressive cytokines such as IL6 and VEGF. These results suggested that MSC induced caner immune evasion in the cancer microenvironment and can be an attractive target for the restoration of immune competence of cancer patients.