Mechanism of neurotoxicity induced by oseltamivir and NSAIDs under the inflammatory conditions

奥司他韦和NSAID用于治疗流感。据报道，在流感患者处方药物中出现了神经毒性，如行为异常和脑病。本研究的目的是检查在炎症条件下的血脑屏障（BBB）的渗透性的奥司他韦或非甾体抗炎药。在本研究中，我们证明：（1）建立了反映炎症的新的体外血脑屏障模型，（2）脑周细胞释放MMP-9，这可能是炎症诱导血脑屏障功能障碍的原因，（3）在炎症条件下，双氯芬酸钠盐的血脑屏障通透性没有改变。

Oseltamivir and NSAIDs are used in the treatment of influenza. Neurotoxicity such as abnormal behavior and encephalopathy has been reported in influenza patients prescribed their drugs. The purpose of the present study is to examine the blood-brain barrier (BBB) permeability of oseltamivir or NSAIDs under inflammatory conditions. In this study, we demonstrated that (1) novel in vitro BBB models reflecting inflammation were developed, (2) brain pericytes released MMP-9 which may be responsible for BBB dysfuction induced by inflammation, (3) the BBB permeability of dicrofenac sodium salts was not changed under inflammatory conditions.