Mesenteric lymph node stromal cells influence the induction of chronic intestinal inflammation

肠道免疫系统的反应性和肠道环境之间的平衡是维持肠道稳态的基础，这是对进入抗原的充分识别所必需的。对无害抗原的过度免疫反应破坏了这种体内平衡，可导致肠道疾病的发展，如炎症性肠病。肠系膜淋巴结（mLNs）是免疫反应诱导的重要部位，也是肠内免疫反应和耐受诱导的重要组成部分。mln由几个特定的肠引流淋巴结组成，其骨干由无底的非造血基质细胞构成。然而，关于结肠引流mLN和基质细胞在炎症反应调节中的作用的知识仍然有限。因此，我们旨在分析结肠引流的mLN及其基质细胞对肠道炎症发展的影响。我们将使用慢性肠道炎症模型，如il10缺陷小鼠，以及C.啮齿动物感染模型。

The balance between the responsiveness of the intestinal immune system and the gut environment is fundamental for the maintenance of the intestinal homeostasis, which is required for an adequate recognition of entering antigens. The disruption of this homeostasis by exaggerated immune response to harmless antigens can lead to the development of intestinal disorders such as inflammatory bowel disease. Mesenteric lymph nodes (mLNs) are an important site for the immune response induction, but also contribute to the immune response and tolerance induction in the intestine. The mLNs consist of several specific intestine draining lymph nodes and their backbone is built by sessile non-hematopoietic stromal cells. However, the knowledge about the role of the colon draining mLN as well as stromal cells in the regulation of inflammatory responses is still limited. Therefore, we aim to analyze the influence of the colon-draining mLN as well as stromal cells of the mLN on the development of intestinal inflammation. We will use a chronic intestinal inflammation model such as the IL10-deficient mouse but also a C. rodentium infection model.