Regulation of juvenile hormone biosynthesis by peptide hormones

幼虫激素是昆虫发育的关键调控因子之一，如；蜕皮、变态、繁殖、等级分化和滞育。在全变态昆虫中，JH决定了蛹变态开始的时间。我们考察了多肽激素对JH生物合成的调节作用。在幼虫期，短神经肽F期依赖抑制JH的生物合成，其表达受AT调控。但AT对幼虫CA活性无明显影响。相反，AT对蛹和成虫的CA均有抑制作用，说明JH的合成受特定阶段肽激素的调控。

Juvenile hormone is one of key regulator of insect development, e.g.; molting, metamorphosis, reproduction, caste differentiation, and diapause. In holometabolous insects, JH determines the timing for initiation of pupal metamorphosis. We examined the regulation of JH biosynthesis by peptide hormones. During larval stages, short neuropeptide F stage dependently inhibited JH biosynthesis, and its expression was regulated by AT. But AT did not show any effect on larval CA activity. In contrast, AT showed inhibitory effect on pupal and adult CA. These results indicate that JH biosynthesis is regulated by stage specific peptide hormones.