Stoffwechsel-Käfigsystem

代谢紊乱与慢性炎症性疾病的发展密切相关，如动脉粥样硬化、糖尿病、非酒精性脂肪性肝炎(NASH)、肠道和骨骼的炎症性疾病以及各种肿瘤。目前的流行病学研究表明，目前世界上超过一半的人口超重，其中肥胖儿童的大量存在尤其令人担忧。这一发展的经济后果尚不可预见，因此迫切需要以科学为基础的新战略来治疗与肥胖有关的疾病。在能量正平衡的情况下，多余的卡路里以脂肪的形式储存在白色脂肪组织中，而耗能的棕色和米色脂肪细胞则形成了所谓的生热脂肪组织。它在寒冷的环境中被激活，以保护人类和其他哺乳动物免受体温下降的影响。此外，生热脂肪细胞具有对抗肥胖和代谢性疾病的潜力。这些产热脂肪细胞的活动，也与免疫细胞活动、肠道内食物的加工、运动和神经系统的调节有关，可以通过间接量热法测定。使用这种非侵入性的方法，可以通过非常准确地测量小鼠在不同环境温度下的昼夜分布的氧气消耗和二氧化碳产生、体温和活动来确定代谢活动。用于确定这些参数的新系统能够实现显著更高的灵敏度和分辨率，因此也可以检测到这些基本代谢参数的变化，例如骨骼系统的炎症变化或疾病。因此，拟议的系统将能够在代谢和炎症之间的界面上进行跨器官的系统分析，以便更好地了解不同环境温度和饮食下的代谢变化对脂肪组织、肝脏、骨骼、中枢神经系统和肠道慢性炎症性疾病发展的意义。这些研究由四个不同的研究小组在DFG资助的单个项目和汉堡-埃彭多夫大学医学中心(UKE)的合作研究中心的框架内进行。因此，间接量热法系统将支持指定的以免疫学、免疫学、感染学(C3i)为重点的UKE研究。按照计划，申请者还将把这项技术作为核心设施单位提供给其他研究小组。

Metabolic disturbances are causally involved in the development of chronic inflammatory diseases such as atherosclerosis, diabetes, non-alcoholic steatohepatitis (NASH), inflammatory diseases of the intestines and bones and various tumours. Current epidemiological studies show that more than half of the world population is now overweight, with the high number of obese children being a particular cause for concern. The economic consequences of this development are not yet foreseeable, so that new science-based strategies for the treatment of obesity-related diseases are urgently needed. With a positive energy balance, excess calories are stored as lipids in the white fat tissue, while the energy-consuming brown and beige fat cells form the so-called thermogenic fat tissue. This is activated in cold environments to protect humans and other mammals from a drop in body temperature. In addition, thermogenic fat cells have the potential to counteract obesity and metabolic diseases. The activity of these thermogenic fat cells, also in connection with immune cell activity, the processing of food in the intestine, exercise and regulation by the nervous system, can be determined by indirect calorimetry. Using this non-invasive method, metabolic activity can be determined by the very accurate measurement of oxygen consumption and carbon dioxide production, body temperature and activity in the day and night profile at different ambient temperatures in mice. New systems for the determination of these parameters enable a significantly higher sensitivity and resolution, so that changes in these elementary metabolic parameters can also be detected, e.g. in inflammatory changes or diseases of the skeletal system. The proposed system will thus enable cross-organ systematic analyses at the interface between metabolism and inflammation in order to better understand the significance of metabolic changes at different ambient temperatures and diets for the development of chronic inflammatory diseases in the fatty tissue, liver, bones, central nervous system and intestine. The studies are conducted by four different research groups within the framework of DFG-funded individual projects and collaborative research centres at the University Medical Center Hamburg-Eppendorf (UKE). The system for indirect calorimetry would thus support the designated UKE research focus on Immunology, Immunity, Infection (C3i). It is planned that the applicant will also offer the technology to other research groups as a core facility unit.