Temporal imaging of epileptic activity in animal models

本研究通过对小鼠和大鼠海马区急性点燃和注药所致癫痫样发作过程中脑血流量(CBF)的变化进行检测，以揭示癫痫的发生发展过程。因此，我们发现扣带回可能介导癫痫样发作对运动皮质的传播。此外，还证实了癫痫发作时双侧脑血流量的改变。提示癫痫样发作引起的代谢性改变可能发生在双侧，并伴有局域场电位的改变。

In this study, we measured the alteration of cerebral blood flow (CBF) during epileptiform seizure induced by acute kindling and drug injection of the mouse and rat hippocampus to reveal the progression of epileptic activity. In consequence, we found cingulate gyrus might mediate propagation of epileptiform seizure for motor cortex. Additionally, it was confirmed alteration of CBF during epileptiform seizure occured bilaterally. It was suggested that metaboric change caused by epileptiform seizure might occur bilaterally and accompany change of local filed potentials.