Studies on production of taxol (anticancer agent) from natural sources.

紫杉醇是最有前途的天然抗癌药物之一，已被证明对卵巢癌、乳腺癌和肺癌的治疗有效。紫杉醇是一种发现于红豆杉属植物中的二萜，发现于东北红豆杉中。调查。它生长在日本。虽然对紫杉醇的需求在稳步增长，但这种药物的供应是有限的。本研究建立了一种从栽培虎杖树中提取紫杉醇的方法。由此可见，从森林资源中提取紫杉醇是可行的。在日本，从短轮作集约化人工林中提取紫杉醇是一种有吸引力的生产紫杉醇的方法。本研究对产自日本的紫杉树中紫杉醇、baccatin III和10-去乙酰baccatin III的含量进行了测定，并开发了一种从森林资源中提取紫杉醇的有效方法。提出了利用森林资源生产紫杉醇作为森林管理政策的一部分的可能性。

Taxol is one of the most promising natural-product anti-cancer drugs and has been shown to be effective in the treatment of ovarian, breast and lung cancers. Taxol, a diterpene found in Taxus spp., is found in Taxus cuspidata Sieb. Et Zucc., which grows in Japan. Although the demand for taxol is steadily increasing, the supply of the drug is limited. We performed studies to establish a method of extracting taxol from cultivated T.cuspidata trees. From these results, it was considered possible to extract taxol from forest resources. Extraction of taxol from renewable resources such as seedlings of T.cuspidata on short-rotation intensive-culture plantations was considered to be an attractive approach for the production of taxol in Japan. In summary, the contents of taxol, baccatin III and 10-deacetylbaccatin III in T.cuspidata growing in Japan were examined, and an efficient extraction method to produce taxol from forest resources was developed. The possibility of producing taxol from the forest resources as part of the forest administrat ion policy was suggested.