Histopathological Study for the Development of Adhesive Resin Systems with a Calcification Promoting Function as a Direct Pulp Capping Agent

猕猴直接盖髓的组织病理学研究结果表明，粘接树脂对牙髓组织无刺激性，如果有刺激性，刺激性极低，并且材料之间存在差异。当牙髓受到保护，并通过使用适当选择的粘合树脂直接盖住牙髓时。新的牙本质在牙髓裸露的表面形成，随着时间的推移，它应该延伸到完整的牙本质桥。用粘结树脂与Ca(OH)2杂化后，不需要无机水泥作为基层和基层材料。对于3%H_2O_2~6%NaOCl和7%H_2O_2~10%NaOCl交替清洗剂对牙本质屑的冲洗效果，较高浓度的清洗剂并不总是表现出较好的牙髓清洗效果或创面愈合性能。对于激光照射暴露的牙髓表面的影响，没有伤口愈合的积极反应(…对本实验中使用的照射条件有更多的认识。在两家制造商的协助下，对开发具有直接盖髓作用的钙化促进作用的粘接树脂系统进行了组织病理学研究。综上所述，实验开发的苯基-P体系中的PR2B和PR2基团以及4-META/MMA-TBB体系中含3%、5%和10%Ca(OH)_2的聚合物作为直接盖髓剂的可能性很大。在患者同意的情况下，对保守治疗期间意外暴露的牙髓或牙髓壁上发现的粉红色斑点直接或间接地用粘结树脂盖上牙髓的长期临床预后进行调查。共15例患者17颗牙直接盖冠，1颗间接盖牙。牙髓暴露大小平均约为0.7 mm。远期临床预后，平均4年13例患者16颗牙(88.9%)极好。2例患者(11.1%)的牙髓因牙髓坏死而失活。长期的临床结果清楚地支持了以前的研究结果。也就是说，结果表明，粘接树脂对牙髓组织的刺激性极低。结论：粘接树脂在某些情况下是一种合适的临床直接盖髓材料。同时，还需要对牙髓诊断和牙齿修复模式进行进一步的研究。较少

The results of a histopathological study of direct pulp capping in Macaca fascicularis suggested that adhesive resins caused no irritation to the pulp tissue or if so, it was extremely low and differences were found among the materials. When the pulp was protected and safely covered by direct capping using appropriate selected adhesive resins. New dentin formed on the exposed surface of the pulp and it should extend to the complete dentin bridge in the maturation process over time. It was also suggested that no inorganic cement was necessary as the material of the sub-base and base after Ca(OH)_2 hybridization with adhesive resin. Concerning the irrigation effect of dentinal chips between the alternate cleansing agents of 3%H_2O_2-6%NaOCl and 7%H_2O_2-10%NaOCl, higher concentrations of the agents did not always show better cleansing effect or wound healing properties of the pulp. Regarding the laser irradiation effect on the exposed pulp surface, no wound healing effect was actively re … More cognized of irradiation conditions used in this experiment. With the assistance of two manufactures, a histopathological study for the development of adhesive resin systems with a calcification promoting function as a direct pulp capping agent was examined. To summarize, the following experimentally developed materials : PR2B and PR2 groups in the Phenyl-P system and polymers containing 3%, 5% and 10% Ca(OH)_2 in the 4-META/MMA-TBB system showed a high possibility to be used as direct pulp capping agents. With the consent of the patients, the long-term clinical prognosis of the pulp directly or indirectly capped with adhesive resins on accidentally exposed pulp or pink spots found on the pulpal wall in deeply prepared cavities during conservative treatment was investigated. In total, seventeen teeth of 15 patients were capped directly and the remaining one was capped indirectly. The exposed size of the pulp was approximately 0.7mm in average. Long-term clinical prognosis, approximate 4 years in average of sixteen teeth of 13 patients (88.9%) was extremely good. Devitalization of the pulp with pulp necrosis was observed in two teeth of 2 patients (11.1%). The long-term clinical results clearly supported the results obtained in the previous studies. Namely, the results suggested that adhesive resins caused extremely low irritation to the pulp tissue. But differences between the materials were found.To conclude, it was clearly confirmed that adhesive resin is an appropriate material for use in certain cases as a direct pulp capping agent in clinic. At the same time, further investigation on both pulp diagnosis and the restorative pattern of teeth will be required. Less