Transition-Metal Catalyzed Novel and Useful C-C Bond Formation and Cleavage

烯丙醇是最有用的烯丙基碳源，因为它们稳定、廉价、普遍存在于自然界中。然而，由于它们的低化学反应活性，它们很少用作C3-单元。本研究揭示了烯丙醇作为C-3单元的潜力;它们在Et_3B或Et_2Zn存在下不仅作为烯丙基阳离子，而且作为烯丙基阴离子在钯的催化反应中起作用。即Pd-Et 3B促进1）活性亚甲基化合物的烯丙基化，2）胺的烯丙基化，3）醛的α位烯丙基化。另一方面，Pd-Et 3B或Pd-Et 2 Zn通过直接使用烯丙醇本身来帮助醛和酮的亲核烯丙基化。所有这些反应都在室温下甚至在水的存在下进行。所有这些与使用烯丙醇作为起始材料相关的特征结合起来联合收割机有助于学术进步，也有助于产生环境友好和经济上有利的反应。

Allyl alcohols are the most useful allyl carbon source, since they are stable, cheep, ubiquitous in nature. However, they have utilized scarcely as C3-unit owing to their low chemical reactivity. This research have disclosed the potential of allyl alcohols as the C-3 unit; they serve not only as allyl cations, but also as allyl anions in the catalytic reactions of palladium in the presence of Et3B or Et2Zn. That is, Pd-Et3B promotes 1) allylation of active methylene compounds, 2) amines, 3) α-position of aldehydes. On the other hand, Pd-Et3B or Pd-Et2Zn helps nucleophilic allylation of aldehydes and ketones by direct use of allyl alcohols themselves. All these reactions proceed at room temperature and even in the presence of water. All these features associated with the use of an allyl alcohol as a starting material combine to contribute to academic advancement, also to creating reactions that are environmentally friendly and economically advantageous.