Mechanisms of graft sclerosis by advanced glycation end product deposition - With the aim of elucidation of arteriosclerosis and development of therapy for arteriosclerosis

目的：内侧弹力板是抵抗动脉粥样硬化危险因素的屏障：晚期糖基化终产物(AGE)可导致糖尿病患者动脉内蛋壳钙化。材料与方法胸内动脉取自13名男性和3名女性(年龄15-79岁)，尸检时无动脉硬化和糖尿病。用自体荧光检测方法研究AGE在胸内动脉的沉积。形态计量学测量胸内动脉的内侧厚度和内侧弹性板数。结果16具身体胸廓内动脉均可见AGE沉积。胸内动脉AGE沉积程度随增龄而增加。胸内动脉的中层厚度随增龄而增加，而胸内动脉的弹性板数则减少。结论随着年龄的增加，胸内动脉弹性板层对动脉粥样硬化的防御机制减弱。

Purpose Medial elastic lamellae works as a barrier against atherosclerotic risk factors: Advanced glycation end product (AGE) causes egg shell calcification in arteries of diabetic patients. This study assessed AGE deposition in medial elastic lamellae of internal thoracic arteries.Materials and Methods Internal thoracic arteries were obtained from 13 males and 3 females (aged 15-79 years) who did not suffer from arteriosclerosis and diabes at autopsy. AGE deposition in internal thoracic arteries was studied by autofluorescence detection method. Medial thickness and number of medial elastic lamellae of internal thoracic arteries were measured by morphometry. Results AGE deposition was detected in all internal thoracic arteries of 16 cadavers. Degree of AGE deposition in internal thoracic arteries was increased with aging. Medial thickness of internal thoracic arteries also increased with aging, while number of elastic lamellae of internal thoracic arteries decreased.Conclusion Defense mechanism of medial elastic lamellae against atherosclerosis may reduce due to AGE deposition with aging.