Development of Practical Electron Transfer Driven Reactions for Organic Synthesis

我们的目标是开发一种实用的电子转移驱动有机合成反应，并在“阳离子池”方法的基础上开发了“阳离子流”方法。在“阳离子流”方法中，使用低温电化学微流反应器产生的碳阳离子立即被碳亲核捕获。电化学流动反应器的小型化可以实现有效的温度控制和缩短停留时间，因此该系统可以应用于不稳定的碳正离子。我们还开发了一套利用FITR光谱仪直接分析碳正离子流动的系统。“阳离子流”体系更突出的特点是通过简单的流量切换即可实现连续有序组合合成。虽然平行合成在组合化学中有着广泛的应用，但目前的连续顺序方法为组合合成开辟了一个新的有趣的方面。

We aimed to develop a practical electron transfer driven reaction for organic synthesis, and a "cation flow"method has been developed on the basis of the "cation pool" method. In the "cation flow" method, carbocations generated using a low temperature electrochemical microflow reactor were immediately trapped with carbon nucleophies. Downsizing of a electrochemical flow reactor enables efficient temperature control and shortening ofa residence time, and thus an application of this system to less stable carbocation could be possible. We have also developed a direct analysis system of the flow of the carbocations using FITR spectrometer. More outstanding feature of the "cation flow" system is that continuous sequential combinatorial synthesis can be accomplished by simple flow switching. Although parallel syntheses enjoy versatile applications in combinatorial chemistry, the present continuous sequential method opens a new intriguing aspect of combinatorial synthesis.