The method of estimation of stress in child abuse/neglect

在法医尸检中，很难评估涉嫌虐待/忽视儿童案件的压力程度。为探讨虐待对胸腺细胞分化的影响，我们观察了虐待/忽视儿童胸腺的形态学变化和胸腺细胞亚群的比例。我们发现，CD 4 + CD 8+双阳性（DP）胸腺细胞的相对数量减少，在虐待/忽视儿童。推测受虐待/忽视儿童胸腺退化可能是由于CD_3、bcl-2 ~+标记的未成熟DP胸腺细胞数量选择性减少<- to low><low>所致。有人建议，胸腺细胞亚群的比例的变化可能是一个指数的压力的情况下，虐待/忽视。

It is difficult to evaluate the extent of stress in cases of suspected child abuse/neglect in a medico-legal autopsy. To elucidate the influence upon thymocytes differentiation, we investigated that the morphological change of the thymus and the proportion of the thymocyte subpopulation in abused/neglected children. We found that the relative number of CD4+CD8+ double positive (DP) thymocytes decreased in the abused/neglected children. It was presumed that the selective decrease in the number of the immature DP thymocytes with CD3 ^<- to low> bcl-2^<low> caused the thymic involution in the abused/neglected children. It is proposed that the alteration in the proportion of thymocyte subpopulations could be an index for the degree of the stress in cases of child abuse/neglect.