The protective effects of sphingolipid synthetic drug (L-PDMP) on apoptotic cell damage in cerebral infarction

L-脯氨酸（L-苏型-1-苯基-2-癸酰氨基-3-吗啉基-1-丙醇）对神经元鞘糖脂的合成具有促进作用，并具有神经营养作用。本研究观察了腹腔注射L-磷脂酰胆碱对大脑中动脉（MCA）永久性闭塞大鼠神经鞘脂代谢和行为学的影响。L-PdR治疗诱导缺血大脑皮层中葡糖神经酰胺（神经节苷脂前体）和鞘磷脂（SM）水平的增加，并改善Morris水迷宫任务中记忆和学习的获得。已提出L-PdR的药理作用在促进细胞存活和改善神经功能方面具有显著活性。

L-PDMP (L-threo-l-phenyl-2-decanoylamino-3-morpholino-l-propanol) exhibits stimulatory effects on glycosphingolipid biosynthesis and its neurotrophic actions in cultured neuron. The effects of intraperitoneal administration of L-PDMP on sphingolipid metabolism and behavioral changes in the rat following permanent occlusion of the left middle cerebral artery (MCA) were investigated. The L-PDMP treatment induced increases in glucosylceramide (ganglioside precursor) and sphingomyelin (SM) levels in the ischemic cerebral cortex, and improved acquisition of memory and learning in the Morris water maze task. The pharmacological effects of L-PDMP have been proposed to have a significant activity on promoting cell survival and improving neural functions.