Iodine laser development which oscillates with singlet delta oxygen produced by electric discharge, and its application for biological tissue fusion

放电氧碘激光器（DOIL）是欧美国家为机载激光系统应用而研制的一种新型激光器，特别是我国最大的竞争对手美国CU-Aerospace公司，在美国空军的预算支持下，正在积极进行DOIL的研究。自2000年在世界上率先检测到DOIL发射的光放大后，我们一直在努力通过改进系统达到兆瓦级的功率输出，直到2003年5月底。但不仅是我们，外国团队也可以清除这个目标。通过这3年的研究，取得的丰硕成果有3项，即；提出了提高产率、碘解离和激光气体冷却等对mW功率输出的影响，并对各项目建立了可行的指标和设计数据。幸运的是，我们成功地为DOIL研究获得了新的预算，并为实现2004年的振荡做出了巨大的努力。针对激光在生物组织融合中的应用，采用与DOIL波长相近的YAG激光束对大鼠胃大动脉进行了焊接试验。从融合部位的组织学术观点来看，异物的异常反应很难被接受，激光恢复融合组织的时间比螺纹恢复的早，早期出现的收缩情况很快消失。为了抑制这种方法中容易出现的动脉瘤的产生，我们用肌肉膜覆盖动脉来加强融合位置。结果动脉瘤完全消失，融合组织变性或坏死等并发症长期未见。我们认为动脉激光融合是一种很好的肌肉膜加固方法。

The Discharge Oxygen-Iodine Laser (DOIL) has been developed for the application of airborne laser system in Europe and the U.S. Especially, CU-Aerospace Co. in the US, who is our biggest competitor, is doing DOIL research very actively under a budget of US Air Force. After having detected the light amplification of DOIL emission first in the world in 2000, we have been trying to achieve mW power out-put by improving the system till the end of May 2003. But not only us but foreign teams can clear this target. Fruitful results, which obtained through this 3 years research term, are that 3 items, i.e.; increasing yield, iodine dissociation and laser gas cooling, are picked up for the mW power out-put, and feasible targets and the design data are established for each item. Fortunately, we are successful in getting a new budget for the DOIL research and doing big efforts for achieving oscillation on 2004.Concerning laser application for biological tissue fusion, welding tests of the main artery at a rat stomach were carried out using YAG laser beam which has a similar wavelength of DOIL. From the tissue scholarly view at fused position, it can be said that the abnormal reaction by foreign substance was hardly accepted, the fused tissue was recovered earlier by the laser than by the thread, and the constriction condition which appeared at early stage was soon disappeared. In order to suppress the aneurysm generation which tend to appear in this method, the fusion position was reinforced by covering artery with muscles film. As the results, the aneurysm completely disappeared and complications, such as denaturation or necrosis of fused tissue, were not observed for long-term. We conclude that the laser fusion on artery is an excellent method with the muscles film reinforcement.