Switching of spatio-temporal Rho GTPase signal network dynamics during cell cycle phase transitions (A08)

Nalbant旨在揭示细胞骨架调节剂的时空活动动力学和基本细胞形状变化在生理和病理生理背景下的细胞状态转换期间是如何控制的。由于细胞形状的变化是由肌动蛋白丝，反过来又是由Rho GTdR信号网络控制的动态restore-ments驱动的，她将研究Rho活性动力学的功能和鸟嘌呤核苷酸交换因子的复杂调节，以及它们如何被触发和连接到戏剧性的细胞状态转换利用先进的活细胞显微镜和急性光遗传学调制。

Nalbant aims to unravel how spatio-temporal activity dynamics of cytoskeletal regulators and fundamental cell shape changes are controlled during cell state transitions in physiological and pathophysiological contexts. Because cell shape changes are driven by dynamic rearrange-ments of actin filaments that in turn are controlled by Rho GTPase signal networks, she will study the function of Rho activity dynamics and their complex regulation by guanine nucleotide exchange factors and how they are triggered and linked to the dramatic cell state transitions utilizing advanced live-cell microscopy and acute optogenetic modulation.