Clinical Research on the Development of Non-myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Refractory Gastrointestinal

采用非清髓性异基因造血干细胞移植治疗难治性结肠癌。患者为45岁女性，患有转移性结肠癌。转移部位位于肝脏、淋巴结和腹腔内（腹膜播散）。供体是她HLA完全匹配的哥哥。在环磷酰胺和氟达拉滨的非清髓性和免疫抑制化疗后，进行了异基因外周血干细胞移植（微型移植）。虽然移植物抗宿主病（GVHD）在移植后35天被发现，但肿瘤没有缩小，她在移植后64天死于癌症。

Non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory colon cancer was performed. The patient was a 45-year-old female with metastatic colon cancer. Metastatic sites were located in the liver, lymph nodes, and intra-peritoneal cavity (peritoneal dissemination). The donor was her HLA full-matched elder brother. After non-myeloablative and immunosuppressive chemotherapy with cyclophosphamide and fludarabine, allogeneic peripheral blood stem cell transplantation was performed (mini-transplantation). Although graft-versus-host disease (GVHD) was recognized 35 days after transplantation, tumor shrinkage didn't occur and she died of cancer 64 days after transplantation.