A longitudinal study on correlation between weight cycling and changes of risk factors for lifestyle-related disease of middle and advance ages

本研究的目的是阐明体重循环与生活方式相关疾病危险因素变化的相关性。研究对象为连续几年在A市就诊的中老年健康体检人员。按体脂百分比分为肥胖组、中度组和瘦肉组，连续数年观察其体脂百分比的波动，并将其分为3个亚组(减肥组、不变化组和增重组)，并与每组的3个亚组进行比较，结果如下：在男性中，中度组SBP、DBP、TC、LDL-C、RBC、Hb、Ht下降有统计学意义。不变亚组Hb显著升高。其他亚组无明显变化。在女性瘦肉组中，下降亚组的TC、LDL-C和TG显著下降。中度组r-GPT、Hb、Ht显著升高。在肥胖组中，糖化血红蛋白下降亚组明显升高。

The purpose of this study is to elucidate the correlation between weight cycling and changes of risk factors for lifestyle-related diseases.The subjects are middle aged and advanced aged who have consulted health medical examination in the city of A for several years in succession. We divided them into three groups (obesity group, moderate group and lean group) by their body fat %, and we observed their fluctuation of body fat % for several years and divided them into three subgroups (decreasing group, unchangeable group and increasing group).We compared the fluctuation with three subgroups in each groups.The results were as follows. In males, decreasing subgroup of moderate group had a statistically significant decrease in SBP, DBP, TC, LDL-C, RBC, Hb, Ht. Unchangeable subgroup had a significant increase in Hb. Other subgroups had no significant changes. In lean group of females decreasing subgroup had a significant decrease in Tc, LDL-C and TG. Moderate subgroup had a significant increase in r-GPT, Hb and Ht. In obesity group decreasing subgroup had a significant increase in HbAlc.