Constructions of Wearable Digital Recorder Equipped with Widehand Amplifier and Its Application Softwares

在认知和行为神经科学中，测量包括自然日常生活在内的各种环境中的生物信息是很重要的。为了实现这一点，我们的目的是构建一台带有宽带放大器的多通道可穿戴数字测谎仪，并验证其实用性。其规格说明如下。最大采样频率：1 kHz，大容量闪存，噪声水平：P-p2μV(高达300 Hz)，通道数：24ch，重量：300g，最大记录时间：24小时或更长，带宽和增益：可编程，刺激/测量/采样参数：自适应设置。所有电路均采用CMOS型工艺制作。此外，还开发了波形观察器、数据格式转换器等应用软件。为了验证其适用性，将所构建的体系应用于人体和动物研究，结果总结如下。(1)测量结果为Perf…更适合患有睡眠障碍的牙科患者。无论牙科治疗后疾病是否缓解，都要进行定量检查。经证实，经治疗后，多导睡眠图显示睡眠质量得到改善。(2)由于该系统具有较宽的带宽和多个通道的特点，所以我们将其与人体脑电一起进行了快速眼动预期前电位(Rapps)的测量。同时测定眼跳前峰电位(PsSP)。通过对测量的RAPPS和PsSP的详细分析，推测了可能的生理来源。(3)多道同步记录大鼠自由活动状态下的隐匿性脑电、海马区和脑干区脑电。在快速眼动睡眠中，海马区θ波与Pgo波/Rms之间存在稳定和瞬时的相关性。这些新颖的发现归功于所构建的系统的特点，如宽带、多通道和大容量存储，这验证了其在医疗和生物应用中的有效性。较少

In cognitive and behavioral neurosciences, it is important to measure biological information in diverse environments including natural daily life. In order to realize this, constructing a multichannel wearable digital polygraph with wideband amplifiers and confirming its usefulness are our purpose. Its specification is described as follows. Maximum sampling frequency : 1kHz, Flash memory with large capacity, Noise level : p-p2μV (up to 300Hz), Channel number : 24ch, Weight : 300g, Maximum recording time : 24hr or longer, Bandwidth & Gain : programmable, Stimulus/Measurement/Sampling Parameters : adaptively set. All the circuits are made by CMOS technology. The system construction was ordered to Digitecs Co. Ltd. In addition, application softwares such as waveform viewer and transformer of data format were made. Thus constructed system was subject to applications to human and animal studies so as to verify its applicability The results are summaried as follows. (1)Measurements were perf … More ormed for the dental patients suffering from sleep disorder. Quantitative examination was done whether or not the disorder was relaxed by the dental treatment. It was confirmed that the quality of sleep in terms of the polysomnograph was improved by the treatment. (2)Spike-like rapid eye movement anticipatory pre-potentials (RAPPS) were measured together with human electroencephalogram, which is owing to the specification that the system was equipped with the wider bandwidth and many channels. Pre-saccade spike potentials (PsSP) were also measured. Through elaborate analysis of measured RAPPS and PsSP, possible physiological origins were inferred. (3)Simultaneous multi-channel recording of electroocculogram, and hippocampal and brainstem EEGs were measured in rats under free-moving situations. Steady and instantaneous correlations between hippocampal θ wave and PGO wave/REMs was found during rapid eye movement (REM) sleep. These novel findings thank to the specification of constructed system such as the wide bandwidth, multiple channels, and a large amount of storage, which verifies the usefulness in the medical and biological applications. Less