Development of Totally Implantable, Permanent, Clinical Artificial Heart System Through Chronic Animal Studies

本研究旨在研制完全植入式、永久性、临床应用的心室辅助装置（VAD）和全人工心脏（TAH）。至于系统的长期耐用性，我们成功地在模拟的内部生理条件下连续运行VAD超过3个月。关于器械的体内评价，5头小牛的实验在5、6、17、17、18天后终止，可能是由于人工瓣膜和连接系统周围的血栓栓塞并发症、抗凝治疗等，而不是由于血泵内的血栓形成。随着术后动物护理的改善，我们应该能够在不久的将来获得长期存活。至于TAH，我们成功地制定了将TAH植入70-90 Kg小牛的所有必要程序，并获得了30小时的存活。在VAD研究的基础上，我们将继续改进系统，为未来提供可靠的TAH系统。我们还致力于开发磁悬浮和流体动力悬浮离心血泵。一个原型磁悬浮系统已经成功地设计，目前正在进行体外评价，其次是在体内评价

In this study, we aimed at development of totally implantable, permanent use, clinical ventricular assist device (VAD) and total artificial heart (TAH). As for the long term durability of the system, we were successful in continuously running the VAD in the simulated internal physiological conditions for over 3-month duration. Concerning the in vivo evaluation of the devices, the experiment was terminated after 5, 6, 17, 17, 18 days in 5 calves maybe due to thromboembolic complications around prosthetic valves and connection system, anti-coagulation therapy, etc, but not due to thrombus formation inside the blood pump. With improvement in post-operative animal care, we should be able to obtain long term survival in near futureAs for TAH, we were successful in working out all the necessary procedure in implanting the TAH in 70-90 Kg size calves and in obtaining the 30 hour survival. Together with the VAD study, we will continue to improve the system and to obtain reliable TAH system for futureWe also expended our efforts in developing magnetically and hydrodynamically levitated centrifugal blood pump. A prototype magnetically levitated system has been successfully designed and currently under in vitro evaluation, followed with the in vivo evaluation