Study regarding effects of the radical scavenger on ischemic-induced facial palsy

在一般性恒河中的疱疹病毒的反应和面部神经的二级微血管分化是开发急性周边面部脉冲的必要条件。特别是，facial canal中的神经edema和ischemia的一个非常重要的循环是确定palsy的必要条件。自从发生化学反应以来，人们就已经知道了，可以承诺自由的激进反应，反应性氧物质（ROS）预计将在帕西的发展中发挥关键作用。在这一研究中，我们调查了帕西的事件、ROS的产生，以及在使用激进清道夫Edaravone （Radicut·）后的历史学发现。1.哈特利几内亚猪在本研究中提供了面部帕西的事件53.哈特利猪和中间菜单上的Petrosal分支被构造成原因是因为化学面部帕西。Edaravone在植物种植后被捐赠到21只动物，在种植后2天被捐赠到12只动物。其他20只动物没有被授予Edaravone作为控制权。A中的帕西的事件 ... More nimals treated early low作为对照动物和延迟治疗动物的事件在administration of edaravone.2.Production of ROSROS被测量为dihydrotetramethyirosamine probe （Molecular Probes）。ROS的生产在一种非治疗动物的表面神经中是显而易见的，但在一种被治疗的edaravone动物的表面神经中几乎是正常的。3.对表面神经损伤的历史变化的历史性检验在一个月后对两种治疗和非治疗动物的土壤造成损害的历史性检验。在这一研究中，在两组中显示出严重损伤的大乳头状瘤，但在受edaravone治疗的动物中显示出细胞体和发现的神经再生，尽管非治疗的动物仍然被揭示出严重程度， edaravone在几内亚猪中的受教育的化学面部炎症的发展，并预防了ROS重新标记的生产。在合并中，结果导致了Edaravone打开了一条新的大道，以治疗急性周边面部帕西。Less（低）

The reactivation of herpes virus in the geniculate ganglion and the secondary microvascular disturbance of the facial nerve are essential for development of acute peripheral facial palsy. Especially, a vicious cycle of nerve edema and ischemia in the facial canal is essential for deterioration of palsy. Since ischemia is well known to promote free radical reactions, reactive oxygen species (ROS) is expected to play a crucial role in the development of palsy. In this study, we investigated the incidence of palsy, production of ROS, and histological findings after use of a radical scavenger, edaravone (Radicut・).1.The incidence of facial palsy53 Hartley guinea pigs served in this study and the petrosal branch of the middle meningeal artery was obstructed to cause ischemic facial palsy. Edaravone was given to 21 animals just after obstruction of the artery and to 12 animals 2 days after obstruction. The other 20 animals were not given edaravone as controls. The incidence of palsy in the a … More nimals treated early was remarkably low as compared to control animals and the incidence in late treated animals significantly decreased after administration of edaravone.2.Production of ROSROS was measured by dihydrotetramethyirosamine probe (Molecular Probes). The production of ROS was remarkable in the facial nerve of a non-treated animal, but it was nearly normal in the facial nerve of an edaravone-treated animal.3.Histological examination of facial nerve damageHistological changes of the facial nerve were investigated 1 month after artery damage in both treated and non-treated animals. The mastoid portion of the facial nerve showed severe damage in both groups but the geniculate ganglion in edaravone-treated animals showed preservation of cell bodies and findings of nerve regeneration whereas non-treated animals still revealed severe degeneration.In this study, edaravone attenuated development of ischemia-induced facial palsy in guinea pigs and prevented the production of ROS remarkably. In conclusion, the results lead that edaravone open the new avenue to the therapy of acute peripheral facial palsy. Less