The Relationship between Breslow Score or Oral Health Score and Sister Chromatid Exchange (SCE) in Human Volunteer's Blood

近年来，有许多关于基因的研究，这些研究揭示了人们的生活方式对基因缺陷的影响。认识到人们生活方式的重要性，也进行了几项关于生活方式与一般健康状况之间关系的研究。这项研究旨在证明牙齿健康或一般健康(布雷斯洛评分)与基因之间的关系。在评估牙齿健康状况时，我们使用了Morita等人开发的口腔健康评分。：我们使用问卷调查来获得受试者的牙齿健康状况信息。在研究基因缺陷的存在时，Morimoto等人设计了人类外周血淋巴细胞培养。用于定量测定受试者外周血中姐妹染色单体互换(SCE)。研究结果表明，姐妹染色单体互换与口腔健康得分之间存在弱相关(r=-0.30，p&lt；0.05，贡献率为8.98%)。换句话说，口腔健康得分越高的受试者，姐妹染色单体交换频率越低，这表明根据口腔健康得分拥有健康生活方式的人往往有更少的基因缺陷。但Breslow评分与姐妹染色单体互换均数(30分)之间也无显著相关性(r=0.133)。

In recent years, there have been many studies conducted on genes, which shed light on the impact of people's lifestyle on gene defects. Recognizing the importance of people's lifestyle, there have also been several studies conducted on the relationship between lifestyle and general health conditions. This study was aimed at demonstrating the relationship between dental health or general health (Breslow score) and genes. In evaluating the dental health status, we used the Oral Healthiness Score developed by Morita et al. : we used questionnaires to obtain information about dental health status of the subjects. In investigating the presence of gene defect, the human peripheral lymphocyte culture devised by Morimoto et al. was used for the quantitative measurement of sister chromatid exchange (SCE) in blood samples collected from the subjects. The result of this study showed that there was a weak correlation between SCE and the score value of the Oral Healthiness Score (r=-0.30,p<0.05,contribution ratio of 8.98%). In other words, the higher subjects scored on the Oral Healthiness Score, the lower the SCE rate was, suggesting that people who have healthy lifestyle according to the Oral Healthiness Score tend to have fewer gene defects. However, there was no significant correction between Breslow's score and means of SCE(30), too (r=0.133).