Intervention study on effects of resistance training on endothelial function of middle and elder persons

生活方式相关疾病是动脉粥样硬化和心血管疾病的危险因素。人们尝试了各种关于饮食和运动的健康计划来预防这种疾病。本研究的目的是探讨阻力训练对中老年人内皮功能的影响。本研究是一项随机干预研究，对干预组45名受试者进行为期3个月的抗阻训练。对照组41人，以健康体检为基础进行健康指导。干预组体重和西部环境有中度降低，对照组则有轻微或基本变化。干预组的血脂和血糖水平有所下降，而对照组则没有变化。干预组的急性炎症反应蛋白如hs-CRP和血浆纤维蛋白原明显低于对照组。血管性血友病因子作为内皮功能指标，在两组均有所升高。本研究提示，抗阻训练可以改善动脉粥样硬化相关的炎症反应，其表现为hs-CRP和血浆纤维蛋白原的降低。然而，血管性血友病因子是否适合内皮功能的指标还有待进一步研究。没有测量可能是另一种选择。

Life-style related diseases are risk factors for atherosclerosis and cardiovascular diseases. Various health programs on diet and exercise have been tried for the prevention. The aim of the present study was to investigate the effects of resistance training on endothelial function of middle and elder persons. The present study was conducted as a randomized intervention study where resistance training was done for three months on the intervention group with 45 subjects. For the control group with 41 persons, health guidance based on health checkup was made. Body weight and west circumstance were moderately reduced in the intervention group, while they were slightly or little changed in the control group. Blood lipid and sugar levels were decreased in the intervention group, whereas they were not changed in the control groups. Acute inflammatory reactive proteins such as hs-CRP and plasma fibrinogen reduced in the intervention group more definitely than in the control groups. Von Willebrand factor, as an indicator of endothelial function, increased in both groups. The present study suggested that resistance training may improve inflammatory reaction related to atherosclerosis, which were represented by a reduction of hs-CRP and plasma fibrinogen However, von Willebrand factor need to be further investigated with respect to its appropriate indicator of endothelial function. NO measurement may be the alternative.