Characteristics and standardization of cardiac function in elderly populations

为了使老年人的心脏功能标准化，进行了以下工作。1）在本项目的第一年，日本核医学会（JSNM）组织了一个为期两年的工作组。通过日本医科大学、庆应义塾大学、北海道大学、金泽大学、虎之门医院、东邦大学的成员合作，积累了心肌标准数据。这些项目由每个机构的伦理委员会批准。数据传输到金泽大学中心办公室工作站的格式。在本研究期间，我们联系了Germano博士（美国Cedars Sinai医学中心）和Garcia博士（埃默里大学），他们是常用心肌灌注量化软件的开发人员。2）在2005年11月至2010年12月期间开展的JSNM工作组活动中， ...更多信息 2007年10月，生成心肌灌注、脂肪酸代谢（1-123 BMIPP）和交感神经成像（1-123 MIBG）的标准数据。截止到资助期限，完成了心肌灌注图的标准化工作。JSNM工作组的最终报告将作为JSNM活动的报告发表。3）生成心肌模型并验证1-123放射性药物的定量数据。使用标准体模进行数据采集，并针对不同类型的相机进行标准化。1-123放射性药物的多窗口采集方法是获得可靠数据的最佳实用选择。4）多中心研究，J-ACCESS（Nishimura，Tsunehiko，首席研究员）是日本核心脏病学领域的第一个预后研究。在为研究积累的4670例患者数据中，268例受试者被选为冠心病低风险人群。当计算左心室射血分数和容积的标准值时，女性和男性之间以及不同年龄组之间存在显著差异。本研究强调了人群特异性标准的重要性。少

The following works have been performed for the standardization of the cardiac function in the elderly population.1)In the first year of this project, a two-year working group was organized in the Japanese Society of Nuclear Medicine (JSNM). By the cooperation of the members from Nihon Medical University, Keio-Gijuku University, Hokkaido University, Kanazawa University, Toranomon Hospital, Toho University, myocardial standard data were accumulated. The projects were approved by the ethical committees in each institution. The data were transferred to the format of the workstation in the center office of Kanazawa University. During this study, we took contact with Dr. Germano (Cedars Sinai Medical Center, USA) and Dr. Garcia (Emory University), who are the developer of the commonly available myocardial perfusion quantification software. The collaboration worked effectively in the progress of this project.2)In the JSNM working group activity, which has been performed from November 2005 to … More October 2007, standard data of myocardial perfusion, fatty acid metabolism (1-123 BMIPP) and sympathetic imaging (1-123 MIBG) were generated. By the deadline of the grants-in-aid, we finished the standardization of myocardial perfusion map. The final report from JSNM working group will be published as a report from the JSNM activity.3)Myocardial phantoms were generated and the quantitative data for 1-123 radiopharmaceutical was validated. The data acquisition was performed with the standard phantom, and standardized for the different types of cameras. Multiple-window acquisition method for 1-123 radiopharmaceutical was the best practical choice for the reliable data.4)A multi-center study, J-ACCESS (Nishimura, Tsunehiko, Chief investigator) was the first prognostic study in Japan in the field of Nuclear Cardiology. Among 4670 patients data accumulated for the study, 268 subjects were selected as the low-risk population for coronary artery disease. When standard values were calculated with respect to left ventricular ejection fraction and volumes, significant differences were demonstrated between female and male, and also among different age groups. Importance of population specific standard was emphasized by this study. Less