Noninvasive measurement of human body temperatures using high field magnetic resonance spectroscopy

在这项研究中，我们尝试了非侵入性测量区域温度在正常休息的成年志愿者使用1H磁共振波谱（^1H-MRS）在3 T。通过使用水质子相对于代谢物质子的磁共振化学位移来估计温度。重复测量一名男性的局部脑温48岁）的研究结果表明，在36名志愿者中，^1HMRS可以测量脑温，其误差范围小于0.2（19 - 65岁），18名男性左侧扣带回和额叶附近深部白色物质的温度值分别为37.4±0.4和37.0±0.6 18名女性的平均值为37.4±0.4 ℃和37.4±0.6℃（均数±标准差，配对t检验，P<0.05）。男性额叶温度显著低于女性（P <0.05）。男性深部白色物质温度与鼓膜温度呈显著正相关（r = 0.809，P <0.001），而女性深部白色物质温度与鼓膜温度无显著相关（r = 0.809，P <0.001）.小腿肌肉的温度在室温（21 - 25 ℃）下，腓肠肌（GAS;壳区）和比目鱼肌（SOL;核心区）的温度值分别为35.5±1.5和37.4±1.6（平均值±标准差）（P <0.01）。下肢表面温度从40 ℃变化到10 ℃时，GAS的温度从38.1±1.2 ℃变化到28.0±3.8 ℃，差异有显著性（P <0.0001），SOL的温度变化不显著。1我们可以在生理条件下使用H磁共振波谱（^1H-MRS）无创地测量深部区域的温度。

In this study, we tried to measure the regional temperatures noninvasively in normal resting adult volunteers using 'H magnetic resonance spectroscopy (^1H-MRS) at 3 T. The temperature was estimated by using the magnetic resonance chemical shift of water protons relative to protons of metabolites.1. BRAIN TEMPERATURERepeatedly measured regional brain temperature in one male (48 years old) indicated that the brain temperature could be measured using ^1H MRS with an error range of less than 0.2 Among 36 volunteers (19 -65 years old), values of the temperature at deep white matter near the left cingulate gyms and frontal lobe in 18 males were 37.4±0.4 and 37.0±0.6 (mean±SD significantly different, paired t-test, P<0.05), and those in 18 females were 37.4±0.4 and 37.4±0.6℃ (not significantly different). The temperature at the frontal lobe in the males was significantly lower than that in the females (P <0.05). Moreover, the temperature at the deep white matter in the males, but not in the females, significantly correlated with tympanic temperature (r = 0.809, P <0.001).2. TEMPERATURE OF LOWER LEG MUSCLESThe values of temperature in gastrocnemius (GAS; shell region) and soleus muscles (SOL; core region) at ambient temperature (21 -25 were estimated to be 35.5±1.5 and 37.4±1.6 (mean±SD), respectively (significantly different; P <0.01). Alternation of the surface temperature of the lower leg from 40 to 10 significantly changed the temperature in GAS (P <0.0001) from 38.1±1.2 to 28.0±3.8 However, the temperature in SOL was not significantly affected by this maneuver. 1 We could measure the temperatures at deep regions noninvasively using H magnetic resonance spectroscopy (^1H-MRS) under physiological conditions.