Mitochondrial pathway of apoptosis in target organs of sex steroid hormones

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1)We have shown that the mitochondrial pathway of apoptosis which is regulated by Bcl-2 family proteins, works in uterine epithelial apoptosis after cessation of estrogen stimulation and that number of mitochondrial voltage-dependent anion channel increases, promoting epithelial apoptosis.2)We have shown that the mitochondrial pathway of apoptosis works in apoptosis of androgen-dependent Shionogi 115 carcinoma cells after deprivation of androgen in vito.3)We have shown that fos plays no role in apoptosis of epithelia in the mouse male accessory sex organs and uterus.4)We have shown that degree of epithelial apoptosis in the seminal vesicle or epididymis is much lower during the prepubertal period than after the prepubertal period.5)We established the experimental systems with which we can examine the effect of stromal area on uterine epithelial apoptosis.